PMID- 15001679
OWN - NLM
STAT- MEDLINE
DCOM- 20040513
LR  - 20191210
IS  - 0161-5505 (Print)
IS  - 0161-5505 (Linking)
VI  - 45
IP  - 3
DP  - 2004 Mar
TI  - Application of MRI-based partial-volume correction to the analysis of PET images 
      of mu-opioid receptors using statistical parametric mapping.
PG  - 402-8
AB  - The accurate quantification of brain radioactivity concentration is limited by 
      the spatial resolution of the PET scanner for structures smaller than 2-3 times 
      the resolution. In the presence of enlarged cerebrospinal fluid spaces or regions 
      of cortical neuronal loss, a significant underestimation of gray-matter 
      radioactivity concentration due to the resulting partial-volume averaging can 
      potentially occur. To recover the true radioactivity concentration from PET data, 
      algorithms that use the high-resolution anatomic information provided by MRI have 
      been developed. Their effect on PET quantification has been assessed using 
      regions of interest and non-operator-dependent voxel-based analyses such as 
      statistical parametric mapping (SPM), although the mechanisms that lead to an 
      improvement in PET quantification after partial-volume correction (PVC), compared 
      with no PVC, have not been addressed. METHODS: We studied the influence of our 
      previously described MRI-based PVC algorithm on SPM analysis of age effects on 
      mu-opioid receptor (mu -OR) binding using (11)C-carfentanil PET in 14 healthy 
      subjects (age range, 29-74 y). RESULTS: Mu-OR binding increased with age at a 
      rate of about 0.9% per year in the left temporal cortex after PVC, consistent 
      with the results obtained from human autoradiographic studies. Without PVC, no 
      significant relationship with age was observed. PVC decreased mainly the residual 
      variability of voxel mu-OR binding values around the age regression line. 
      CONCLUSION: MRI-based PVC improves the sensitivity and accuracy of voxel-based 
      statistical analysis of PET data.
FAU - Bencherif, Badreddine
AU  - Bencherif B
AD  - Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, 
      Maryland, USA.
FAU - Stumpf, Martin J
AU  - Stumpf MJ
FAU - Links, Jonathan M
AU  - Links JM
FAU - Frost, James J
AU  - Frost JJ
LA  - eng
GR  - R01 AA11855-01/AA/NIAAA NIH HHS/United States
GR  - R01 AA11872-01A1/AA/NIAAA NIH HHS/United States
GR  - R01 DA12274-03/DA/NIDA NIH HHS/United States
GR  - R01 DA22774-03/DA/NIDA NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Validation Study
PL  - United States
TA  - J Nucl Med
JT  - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
JID - 0217410
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Receptors, Opioid, mu)
RN  - LA9DTA2L8F (carfentanil)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - *Algorithms
MH  - Brain/*metabolism
MH  - Brain Mapping
MH  - Carbon Radioisotopes
MH  - Fentanyl/*analogs & derivatives
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Models, Statistical
MH  - Radiopharmaceuticals
MH  - Receptors, Opioid, mu/*metabolism
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Subtraction Technique
MH  - Tomography, Emission-Computed/*methods
EDAT- 2004/03/06 05:00
MHDA- 2004/05/14 05:00
CRDT- 2004/03/06 05:00
PHST- 2004/03/06 05:00 [pubmed]
PHST- 2004/05/14 05:00 [medline]
PHST- 2004/03/06 05:00 [entrez]
PST - ppublish
SO  - J Nucl Med. 2004 Mar;45(3):402-8.