PMID- 15003941
OWN - NLM
STAT- MEDLINE
DCOM- 20040415
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 286
IP  - 4
DP  - 2004 Apr
TI  - HIFs and tumors--causes and consequences.
PG  - R608-23
AB  - For most organisms oxygen is essential fo life. When oxygen levels drop below 
      those required to maintain the minimum physiological oxygen requirement of an 
      organism or tissue it is termed hypoxia. To counter act possible deleterious 
      effects of such a state, an immediate molecular response is initiated causing 
      adaptation responses aimed at cell survival. This response is mediated by the 
      hypoxia-inducible factor-1 (HIF-1), which is a heterodimer consisting of an 
      alpha- and a beta-subunit. HIF-1 alpha protein is stabilized under hypoxic 
      conditions and therefore confers selectivity to this response. Hypoxia is 
      characteristic of tumors, mainly because of impaired blood supply resulting from 
      abnormal growth. Over the past few years enormous progress has been made in the 
      attempt to understand how the activation of the physiological response to hypoxia 
      influences neoplastic growth. In this review some aspects of HIF-1 pathway 
      activation in tumors and the consequences for pathophysiology and treatment of 
      neoplasia are discussed.
FAU - Hopfl, Gisele
AU  - Hopfl G
AD  - Institute of Veterinary Physiology, University of Zurich, Winterthurerstrasse 
      260, CH-8057 Zurich, Switzerland.
FAU - Ogunshola, Omolara
AU  - Ogunshola O
FAU - Gassmann, Max
AU  - Gassmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Antineoplastic Agents)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Growth Substances)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - DNA-Binding Proteins/chemistry/genetics/*physiology
MH  - Growth Substances/physiology
MH  - Humans
MH  - Hypoxia/physiopathology
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Neoplasms/drug therapy/genetics/pathology/*physiopathology
MH  - Nuclear Proteins/chemistry/genetics/*physiology
MH  - Oncogenes/genetics/physiology
MH  - Oxygen Consumption/physiology
MH  - Phosphorylation
MH  - *Transcription Factors
RF  - 268
EDAT- 2004/03/09 05:00
MHDA- 2004/04/16 05:00
CRDT- 2004/03/09 05:00
PHST- 2004/03/09 05:00 [pubmed]
PHST- 2004/04/16 05:00 [medline]
PHST- 2004/03/09 05:00 [entrez]
AID - 286/4/R608 [pii]
AID - 10.1152/ajpregu.00538.2003 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R608-23. doi: 
      10.1152/ajpregu.00538.2003.