PMID- 15004412
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20190906
IS  - 0918-8959 (Print)
IS  - 0918-8959 (Linking)
VI  - 51
IP  - 1
DP  - 2004 Feb
TI  - Multiple endocrine neoplasia type 1 with unusual concomitance of various 
      neoplastic disorders.
PG  - 75-81
AB  - A patient with multiple endocrine neoplasia type 1 (MEN1) who manifested various 
      MEN1-unrelated tumors was reported. The patient was a 43-year-old woman who 
      manifested typical features of MEN1 including primary hyperparathyroidism, 
      prolactinoma, adrenal adenoma and visceral lipomas. During the course, she also 
      manifested chondrosarcoma, B cell lymphoma and mesothelioma. The patient had no 
      apparent family history of MEN1 or any other neoplastic diseases. Genetic 
      analysis of DNA from peripheral mononuclear cells of the patient revealed no 
      germline mutations in MEN1 gene. Genetic instability due to yet unidentified 
      cause is the possible explanation of occurrence of multiple tumors. Careful 
      periodic screening of endocrine and other disorders for her siblings and children 
      as well as for the patient is warranted.
FAU - Nishimura, Yoshihiro
AU  - Nishimura Y
AD  - Department of Aging Medicine and Geriatrics, Shinshu University Graduate School 
      of Medicine, Matsumoto, Japan.
FAU - Yamashita, Koh
AU  - Yamashita K
FAU - Yumita, Wataru
AU  - Yumita W
FAU - Yamazaki, Masanori
AU  - Yamazaki M
FAU - Katai, Miyuki
AU  - Katai M
FAU - Sakurai, Akihiro
AU  - Sakurai A
FAU - Hashizume, Kiyoshi
AU  - Hashizume K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Alkylating Agents)
RN  - 0 (Epoxy Compounds)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 60OB65YNAB (diepoxybutane)
SB  - IM
MH  - Adenoma/complications
MH  - Adrenal Gland Neoplasms/complications
MH  - Adult
MH  - Alkylating Agents/pharmacology
MH  - Bone Neoplasms/complications
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Chondrosarcoma/complications
MH  - Epoxy Compounds/pharmacology
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/complications
MH  - Lipoma/complications
MH  - Lymphoma, B-Cell/complications
MH  - Magnetic Resonance Imaging
MH  - Mesothelioma/complications
MH  - Monocytes/physiology
MH  - Multiple Endocrine Neoplasia Type 1/*complications/*diagnosis/genetics
MH  - Proto-Oncogene Proteins/genetics
MH  - Tomography, X-Ray Computed
MH  - Viscera
EDAT- 2004/03/09 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/03/09 05:00
PHST- 2004/03/09 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/03/09 05:00 [entrez]
AID - 10.1507/endocrj.51.75 [doi]
PST - ppublish
SO  - Endocr J. 2004 Feb;51(1):75-81. doi: 10.1507/endocrj.51.75.