PMID- 15004787
OWN - NLM
STAT- MEDLINE
DCOM- 20040617
LR  - 20151119
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 51
IP  - 3
DP  - 2004 Mar
TI  - MR properties of excised neural tissue following experimentally induced 
      inflammation.
PG  - 473-9
AB  - Changes in the MR parameters of inflamed neural tissue were measured in vitro. 
      Tumor necrosis factor-alpha (TNF-alpha) was injected into rat sciatic nerves to 
      induce inflammation with negligible axonal loss and demyelination. The MR 
      parameters, such as T1/T2 relaxation and magnetization transfer (MT), were 
      measured 2 days after TNF-alpha injection and were found to be substantially 
      different from those of normal nerves. The average T1/T2 relaxation times 
      increased, whereas the MT ratio (MTR) and the quantitative MT parameter M0B 
      (which describes the semisolid pool of protons) decreased. The MR parameters 
      correlated very well with the extracellular volume fraction (EM) of neural tissue 
      evaluated by quantitative histopathology. The multicomponent T2 relaxation was 
      shown to provide the best quantitative assessment of changes in neural tissue 
      microstructure, and allowed us to distinguish between the processes of 
      inflammation and demyelination. In comparison, the MT measurements were less 
      successful due to competing contributions of demyelination and pH-sensitive 
      changes in the MT effect.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Stanisz, Greg J
AU  - Stanisz GJ
AD  - Imaging Research, Sunnybrook and Women's College Health Sciences Centre, Toronto, 
      Canada. stanisz@sten.sunnybrook.utoronto.ca
FAU - Webb, Stephanie
AU  - Webb S
FAU - Munro, Catherine A
AU  - Munro CA
FAU - Pun, Teresa
AU  - Pun T
FAU - Midha, Rajiv
AU  - Midha R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
RN  - 0 (Coloring Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 15XUH0X66N (Tolonium Chloride)
SB  - IM
MH  - Animals
MH  - Axons/ultrastructure
MH  - Coloring Agents
MH  - Demyelinating Diseases/pathology
MH  - Disease Models, Animal
MH  - Extracellular Fluid
MH  - Hydrogen-Ion Concentration
MH  - Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Myelin Sheath/pathology
MH  - Nerve Degeneration/pathology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Sciatic Nerve/drug effects/*pathology
MH  - Sciatic Neuropathy/chemically induced/*pathology
MH  - Tolonium Chloride
MH  - Tumor Necrosis Factor-alpha/adverse effects
EDAT- 2004/03/09 05:00
MHDA- 2004/06/18 05:00
CRDT- 2004/03/09 05:00
PHST- 2004/03/09 05:00 [pubmed]
PHST- 2004/06/18 05:00 [medline]
PHST- 2004/03/09 05:00 [entrez]
AID - 10.1002/mrm.20008 [doi]
PST - ppublish
SO  - Magn Reson Med. 2004 Mar;51(3):473-9. doi: 10.1002/mrm.20008.