PMID- 15006468
OWN - NLM
STAT- MEDLINE
DCOM- 20041022
LR  - 20121115
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 77
IP  - 3
DP  - 2004 Mar
TI  - Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor 
      agonist CP 55,940 in the social interaction test.
PG  - 567-73
AB  - In spite of the addictive properties of cannabinoids, under certain 
      circumstances, they can evoke strong anxiogenic and aversive responses in humans 
      and in animal tests of anxiety. Effects of different doses of CP 55,940 (10, 20, 
      and 40 microg/kg) were tested in the low-light, familiar (LF) apparatus test 
      condition of the social interaction test. The 40-microg/kg dose of CP 55,940 
      significantly decreased the time spent in social interaction, indicating an 
      anxiogenic effect. This dose also had an independent effect of reducing locomotor 
      activity. In rats tested undrugged 24 h after testing with 40 microg/kg, there 
      was a significant anxiogenic effect, indicating conditioned anxiety. The group of 
      rats injected with 40 microg/kg immediately after the social interaction test 
      showed an unexpected significant anxiolytic effect when tested undrugged 24 h 
      later. In an additional experiment, rats were tested in the high-light, familiar 
      (HF) apparatus test condition after 10 or 40 microg/kg, and only those that were 
      tested after 40 microg/kg showed an anxiogenic effect on the test day and a 
      conditioned anxiogenic effect when tested undrugged 24 h later. Once again, those 
      injected with 40 microg/kg after the social interaction test displayed an 
      anxiolytic effect when tested undrugged 24 h later. We provide the first evidence 
      for unconditioned and conditioned anxiogenic-like responses to a cannabinoid 
      agonist in the social interaction test.
FAU - Genn, Rachel F
AU  - Genn RF
AD  - Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of 
      Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, 
      London SE1 1UL, UK.
FAU - Tucci, Sonia
AU  - Tucci S
FAU - Marco, Eva M
AU  - Marco EM
FAU - Viveros, M Paz
AU  - Viveros MP
FAU - File, Sandra E
AU  - File SE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Cannabinoid Receptor Agonists)
RN  - 0 (Cyclohexanols)
RN  - 0 (Receptors, Cannabinoid)
RN  - 83003-12-7 
      (3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol)
SB  - IM
MH  - Animals
MH  - Anxiety/*chemically induced/psychology
MH  - *Cannabinoid Receptor Agonists
MH  - Conditioning, Operant/*drug effects/physiology
MH  - Cyclohexanols/*pharmacology/toxicity
MH  - Dose-Response Relationship, Drug
MH  - *Interpersonal Relations
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Rats
MH  - Receptors, Cannabinoid/*physiology
EDAT- 2004/03/10 05:00
MHDA- 2004/10/23 09:00
CRDT- 2004/03/10 05:00
PHST- 2003/10/30 00:00 [received]
PHST- 2003/12/16 00:00 [revised]
PHST- 2003/12/17 00:00 [accepted]
PHST- 2004/03/10 05:00 [pubmed]
PHST- 2004/10/23 09:00 [medline]
PHST- 2004/03/10 05:00 [entrez]
AID - S0091305703003964 [pii]
AID - 10.1016/j.pbb.2003.12.019 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Mar;77(3):567-73. doi: 10.1016/j.pbb.2003.12.019.