PMID- 15009177
OWN - NLM
STAT- MEDLINE
DCOM- 20041019
LR  - 20191108
IS  - 0960-7420 (Print)
IS  - 0960-7420 (Linking)
VI  - 31
IP  - 1
DP  - 2004 Feb
TI  - High birth weight is associated with human leukocyte antigen (HLA) DRB1*13 in 
      full-term infants.
PG  - 21-6
AB  - In cord blood banking, substantial amounts of data on infants and cord blood are 
      gathered at high cost, including birth weights and human leukocyte antigen (HLA) 
      genotypes. As certain HLA alleles have been associated with protective host 
      responses, it is possible that an HLA allele, or another factor linked to it, 
      might even affect normal intrauterine growth. We explored cord blood bank data (n 
      = 1381 infants) to elucidate whether there is an association between birth weight 
      and HLA class II (DRB1) alleles. HLA DRB1 data were available from 1263 infants. 
      We observed an association between birth weight and HLA DRB1*13, which was 
      over-represented among full-term infants with the highest birth weights. The 
      association remained when the birth weight was corrected for varying gestational 
      age (relative birth weight) according to gender (P = 0.015). After correction of 
      the P-value for multiple comparisons, the association was not statistically 
      significant. However, when the birth weights of all infants were analysed for the 
      effect of DRB1*13, infants positive for HLA DRB1*13 (n = 319) were found to have 
      higher birth weights than infants negative for this allele (n = 944; median 3690 
      g vs. 3650 g, respectively; P = 0.044). Although the difference in median birth 
      weight was only 40 g, it may be considered significant because it appeared after 
      segregation of the infants into two groups according to the single HLA class II 
      allele group earlier associated with protection against, for example, childhood 
      type 1 diabetes and certain infectious diseases. The present finding may thus 
      suggest identification of a new factor affecting normal intrauterine growth.
FAU - Aroviita, P
AU  - Aroviita P
AD  - Finnish Red Cross Blood Transfusion Service, Helsinki, Finland. 
      pekka.aroviita@bts.redcross.fi
FAU - Partanen, J
AU  - Partanen J
FAU - Sistonen, P
AU  - Sistonen P
FAU - Teramo, K
AU  - Teramo K
FAU - Kekomaki, R
AU  - Kekomaki R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Immunogenet
JT  - European journal of immunogenetics : official journal of the British Society for 
      Histocompatibility and Immunogenetics
JID - 9106962
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Birth Weight
MH  - Female
MH  - Fetal Blood/cytology/metabolism
MH  - Gene Frequency
MH  - Genes, MHC Class II
MH  - Gestational Age
MH  - HLA Antigens/chemistry
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
EDAT- 2004/03/11 05:00
MHDA- 2004/10/20 09:00
CRDT- 2004/03/11 05:00
PHST- 2004/03/11 05:00 [pubmed]
PHST- 2004/10/20 09:00 [medline]
PHST- 2004/03/11 05:00 [entrez]
AID - 434 [pii]
AID - 10.1111/j.1365-2370.2004.00434.x [doi]
PST - ppublish
SO  - Eur J Immunogenet. 2004 Feb;31(1):21-6. doi: 10.1111/j.1365-2370.2004.00434.x.