PMID- 15009387
OWN - NLM
STAT- MEDLINE
DCOM- 20040618
LR  - 20221207
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 43
IP  - 3
DP  - 2004 Mar
TI  - HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis 
      vulgaris in Chinese Han.
PG  - 181-7
AB  - BACKGROUND: Psoriasis vulgaris is a chronic skin disorder characterized by 
      infiltration of inflammatory elements, keratinocyte hyperproliferation and 
      altered differentiation. Although the pathogenesis of psoriasis is not fully 
      understood, there is solid evidence of a susceptibility locus in the human 
      leukocyte antigen (HLA) region. OBJECTIVES: To investigate whether HLA-DQA1 and 
      DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in 
      Chinese Han. PATIENTS AND METHODS: The polymerase chain 
      reaction-sequence-specific primer (PCR-SSP) method was used to analyse the 
      distribution of HLA-DQA1 and DQB1 alleles in 189 patients with psoriasis and 273 
      healthy controls. RESULTS: The HLA-DQA1*0104 (OR = 2.33, P = 0.0001154, Pc = 2.0 
      x 10-3), DQA1*0201 (OR = 3.36, P < 1.0 x 10-7, Pc < 1.0 x 10-6), DQB1*0201 (OR = 
      1.64, P = 0.0192, Pc > 0.05) and DQB1*0303 (OR = 1.55, P = 0.0377, Pc > 0.05) 
      alleles were more prevalent in patients with psoriasis vulgaris than in controls, 
      and HLA-DQA1*0501 (OR = 0.30, P = 0.0000039, Pc < 4.0 x 10-5) alleles were less 
      prevalent. The HLA-DQA1*0104 (OR = 2.42, P = 0.0001159, Pc < 2.0 x 10-3), 
      DQA1*0201 (OR = 3.74, P < 1.0 x 10-7, Pc < 1.0 x 10-6) and DQA1*0501 (OR = 0.30, 
      P = 0.0000374, Pc < 4.0 x 10-4) alleles were only associated with type I 
      psoriasis. HLA-DQA1*0104 and DQA1*0201 were more prevalent in patients with or 
      without a family history of psoriasis. However, the DQA1*0501 allele was only 
      more prevalent in patients without a family history of psoriasis. CONCLUSION: 
      HLA-DQA1*0104 and DQA1*0201 alleles may be psoriasis susceptibility genes or may 
      be in close linkage with the susceptibility genes. The HLA-DQA1*0501 allele seems 
      to have a protective effect against the development of psoriasis vulgaris in 
      Chinese Han. There may be a difference in genetic background between psoriasis 
      patients with and without a family history of psoriasis.
FAU - Zhang, Xuejun
AU  - Zhang X
AD  - Institute of Dermatology, Anhui Medical University, Hefei 230022, China.
FAU - Wei, Shengcai
AU  - Wei S
FAU - Yang, Sen
AU  - Yang S
FAU - Wang, Zaixing
AU  - Wang Z
FAU - Zhang, Anping
AU  - Zhang A
FAU - He, Pingping
AU  - He P
FAU - Wang, Hongyan
AU  - Wang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - China/epidemiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Psoriasis/*genetics
EDAT- 2004/03/11 05:00
MHDA- 2004/06/23 05:00
CRDT- 2004/03/11 05:00
PHST- 2004/03/11 05:00 [pubmed]
PHST- 2004/06/23 05:00 [medline]
PHST- 2004/03/11 05:00 [entrez]
AID - 2098 [pii]
AID - 10.1111/j.1365-4632.2004.02098.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2004 Mar;43(3):181-7. doi: 10.1111/j.1365-4632.2004.02098.x.