PMID- 15009804
OWN - NLM
STAT- MEDLINE
DCOM- 20041104
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 4
DP  - 2004 Apr
TI  - Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study 
      using microsatellite markers.
PG  - 326-34
AB  - Pemphigus is a group of autoimmune blistering diseases of the skin and mucous 
      membranes. The association of pemphigus with human leukocyte antigen (HLA) is 
      widely accepted. It was described in many ethnic groups and in most countries of 
      the world. Studies showed that the associated HLA haplotype in Jewish pemphigus 
      vulgaris (PV) patients is HLA-B38, DRB1*0402, and DQB1*0302; or HLA-B35, 
      DRB1*0402, and DQB1*0302. Similar associations with class II genes were found in 
      Spanish non-Jewish PV patients. As Jews lived in Spain for hundreds of years and 
      many converted to Christianity, the presence of the same HLA haplotype in the 
      Jewish and Spanish PV suggests that they may share the same founder. 
      Microsatellite markers which span the entire major histocompatibility complex 
      (MHC) locus were used as genetic probes. They were utilized to dissect the MHC 
      region in the search for possible common haplotypes, besides HLA, which may 
      provide an answer to this question. It was found that in both cohorts, in 
      addition to HLA class II genes, there are probably genes in the class I region 
      which are associated with PV. Alleles belonging to the associated markers were 
      used to construct haplotypes and to estimate genetic distances. The distance 
      between the two PV cohorts is relatively short, but the distance between the 
      Jewish patients and the Jewish controls is greater compared to the distance 
      between Spanish patients and Spanish controls. In both PV populations, the same 
      microsatellite haplotypes in addition to a common class II haplotype were found, 
      suggesting that both patient populations originated from the same genetic stock 
      and, therefore, share the same ancestral disease gene.
FAU - Loewenthal, R
AU  - Loewenthal R
AD  - The Tissue Typing Laboratory, Chaim Sheba Medical Center, Tel Aviv University, 
      Tel Aviv, Israel.
FAU - Slomov, Y
AU  - Slomov Y
FAU - Gonzalez-Escribano, M F
AU  - Gonzalez-Escribano MF
FAU - Goldberg, I
AU  - Goldberg I
FAU - Korostishevsky, M
AU  - Korostishevsky M
FAU - Brenner, S
AU  - Brenner S
FAU - Nunez-Roldan, A
AU  - Nunez-Roldan A
FAU - Conejo-Mir, J S
AU  - Conejo-Mir JS
FAU - Gazit, E
AU  - Gazit E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - *Jews
MH  - Microsatellite Repeats/*genetics
MH  - Pemphigus/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Spain
MH  - *White People
EDAT- 2004/03/11 05:00
MHDA- 2004/11/05 09:00
CRDT- 2004/03/11 05:00
PHST- 2004/03/11 05:00 [pubmed]
PHST- 2004/11/05 09:00 [medline]
PHST- 2004/03/11 05:00 [entrez]
AID - 191 [pii]
AID - 10.1111/j.0001-2815.2004.00191.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Apr;63(4):326-34. doi: 10.1111/j.0001-2815.2004.00191.x.