PMID- 15011587
OWN - NLM
STAT- MEDLINE
DCOM- 20040730
LR  - 20061115
IS  - 1438-3276 (Print)
IS  - 1438-3276 (Linking)
VI  - 145 Spec No 1
DP  - 2003 Apr 28
TI  - [Immune reconstituted inflammatory syndrome. Pitfalls of antiretroviral therapy].
PG  - 42-7
AB  - The pandemic HIV infection, the more frequent use of immunosuppressive treatment, 
      and the improved long-term prognosis of immunocompromised patients due to better 
      supporting therapies have resulted in an increase in the prevalence of 
      immunodeficiencies. Highly active antiretroviral therapy (HAART) can improve 
      immunocompetence in HIV patients, even when the immunodeficiency is far advanced. 
      This has resulted in an impressive and lasting lowering of the morbidity and 
      mortality associated with HIV infection. However, immune reconstitution may 
      exacerbate subclinical opportunistic infections or autoimmune diseases, or result 
      in an unexpected, paradoxical aggravation of intercurrent inflammatory diseases. 
      The atypical inflammatory conditions have a number of synonymous names: immune 
      restoration disease (IRD), immune reconstitution syndrome (IRS), or immune 
      reconstitution inflammatory syndrome (IRIS). In the light of specific 
      differential therapeutic consequences, it is important to distinguish the 
      clinical presentation from that of corresponding opportunistic infections. 
      However, diagnostic and therapeutic standards for IRIS have not yet been worked 
      out. The present overview also points to possible diagnostic pitfalls, and makes 
      suggestions for a possible classification of the condition and the therapeutic 
      options.
FAU - Stoll, M
AU  - Stoll M
AD  - Abteilung Klinische Immunologie, Medizinische Hochschule Hannover.
FAU - Heiken, H
AU  - Heiken H
FAU - Weber, K
AU  - Weber K
FAU - Hundt, M
AU  - Hundt M
FAU - Behrens, G
AU  - Behrens G
FAU - Schmidt, R E
AU  - Schmidt RE
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Immunrekonstitutionelle inflammatorische Syndrome. Das Janusgesicht der 
      antiretroviralen Therapie.
PL  - Germany
TA  - MMW Fortschr Med
JT  - MMW Fortschritte der Medizin
JID - 100893959
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*drug therapy/immunology
MH  - Autoimmune Diseases/*chemically induced/diagnosis/immunology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Hydroxyindoleacetic Acid/*adverse effects/therapeutic use
MH  - Opportunistic Infections/*diagnosis/immunology
MH  - Risk Factors
MH  - Systemic Inflammatory Response Syndrome/*chemically induced/diagnosis/immunology
EDAT- 2004/03/12 05:00
MHDA- 2004/07/31 05:00
CRDT- 2004/03/12 05:00
PHST- 2004/03/12 05:00 [pubmed]
PHST- 2004/07/31 05:00 [medline]
PHST- 2004/03/12 05:00 [entrez]
PST - ppublish
SO  - MMW Fortschr Med. 2003 Apr 28;145 Spec No 1:42-7.