PMID- 15011740
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20061115
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 55
IP  - 6
DP  - 2003 Nov-Dec
TI  - [Immunogenetics of chronic ulcerative colitis].
PG  - 705-10
AB  - Genetic factors have a definitive role in the etiology of ulcerative colitis 
      (UC). The mode of inheritance suggests a polygenic disease with the penetrance of 
      the genetic factors being strongly influenced by environmental factors. Several 
      studies have been reported associations between UC and the polymorphism of genes 
      that are located in the major histocompatibility complex (MHC) on the short arm 
      of chromosome 6. The human leukocyte antigen (HLA) class II genes are candidates 
      for a role in the pathogenesis of UC, because their products play a central role 
      in the immune response. The MHC region contains numerous immune related genes, 
      and it has now become clear that different alleles of the MHC genes are strongly 
      linked. Association studies have suggested a role for HLA-DR alleles in disease 
      susceptibility to UC. Thus, HLA-DRB1*0103, DRB1*1502 and DRB1*12 were found to be 
      positively associated with UC. On the other hand, the tumor necrosis factor alpha 
      (TNF-alpha) gene encodes a proinflammatory cytokine that is found in increased 
      concentrations in the mucosa of patients with inflammatory bowel disease. The 
      regulation of TNF expression is in part genetically determined because the 
      polymorphisms -238, -308, -863, -857, and -1031 found in the promoter region are 
      associated with increased TNF production. Recent data suggests that TNF 
      polymorphism may be more important in determining susceptibility to UC and these 
      TNF markers could predict response to infusion with chimeric anti-TNF antibody.
FAU - Yamamoto-Furusho, Jesus K
AU  - Yamamoto-Furusho JK
AD  - Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y 
      Nutricion Salvador Zubiran, Mexico, DF. kazuofurusho@hotmail.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Inmunogenetica de la colitis ulcerosa cronica inespecifica.
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la 
      Nutricion
JID - 9421552
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Colitis, Ulcerative/*genetics/*immunology
MH  - Cytokines/genetics
MH  - Genes, MHC Class II
MH  - Humans
MH  - Immunogenetics
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/genetics
RF  - 36
EDAT- 2004/03/12 05:00
MHDA- 2004/06/02 05:00
CRDT- 2004/03/12 05:00
PHST- 2004/03/12 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2004/03/12 05:00 [entrez]
PST - ppublish
SO  - Rev Invest Clin. 2003 Nov-Dec;55(6):705-10.