PMID- 15011784 OWN - NLM STAT- MEDLINE DCOM- 20040521 LR - 20131121 IS - 1464-8431 (Print) IS - 1464-8431 (Linking) VI - 6 IP - 1 DP - 2004 Feb TI - Fashioning regulatory dendritic cells: what is currently in vogue? PG - 78-82 AB - Dendritic cells (DCs) are uniquely well-equipped antigen-presenting cells with remarkable plasticity, whose differentiation and function can be manipulated in vitro and in vivo. With increased understanding of their immunoregulatory properties, strategies to enhance DC tolerogenicity have emerged. Carefully fashioned DCs, the result of biological, pharmacological or genetic modification, hold promise as new cell-based therapies of organ allograft rejection and autoimmune diseases. FAU - Taner, Timucin AU - Taner T AD - University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute, Department of Surgery, 200 Lothrop Street, Biomedical Science Tower W1544, Pittsburgh, PA 15213, USA. FAU - Thomson, Angus W AU - Thomson AW LA - eng GR - AI/DK51698/AI/NIAID NIH HHS/United States GR - AI41011/AI/NIAID NIH HHS/United States GR - DK49745/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - England TA - Curr Opin Mol Ther JT - Current opinion in molecular therapeutics JID - 100891485 SB - IM MH - Animals MH - Antigen Presentation MH - Autoimmune Diseases/therapy MH - Autoimmunity MH - Cell Differentiation MH - Cell- and Tissue-Based Therapy MH - Cells, Cultured MH - Dendritic Cells/*immunology MH - Genetic Engineering MH - Humans MH - Immune Tolerance MH - Models, Biological MH - Transplantation Tolerance RF - 41 EDAT- 2004/03/12 05:00 MHDA- 2004/05/22 05:00 CRDT- 2004/03/12 05:00 PHST- 2004/03/12 05:00 [pubmed] PHST- 2004/05/22 05:00 [medline] PHST- 2004/03/12 05:00 [entrez] PST - ppublish SO - Curr Opin Mol Ther. 2004 Feb;6(1):78-82.