PMID- 15012021
OWN - NLM
STAT- MEDLINE
DCOM- 20040630
LR  - 20190906
IS  - 0393-2990 (Print)
IS  - 0393-2990 (Linking)
VI  - 19
IP  - 1
DP  - 2004
TI  - Markers of fetal growth and serum levels of insulin-like growth factor (IGF) I, 
      -II and IGF binding protein 3 in adults.
PG  - 41-7
AB  - Fetal growth has been linked with increased risk of cancer and cardiovascular 
      disease later in life. The insulin-like growth factor (IGF) axis has recently 
      been proposed as a predictor of risk of subsequent cancer and cardiovascular 
      disease. However, only few data are available on the possible association between 
      fetal growth and levels of IGFs later in life. We examined the association 
      between markers of fetal growth, i.e. birth weight, birth length and Ponderal 
      Index, from birth records and serum IGF-I, IGF-II, and IGF binding protein 3 
      (IGFBP-3) levels in 545 middle-aged Danish men and women. We fitted separate 
      multivariate models including birth weight, birth length, Ponderal Index and 
      serum IGF-I, IGF-II, and IGFBP-3, respectively. After adjustment for age, alcohol 
      intake, smoking, diabetes mellitus, systolic and diastolic blood pressure, serum 
      total cholesterol and current height and weight, we found negative associations 
      between birth weight and Ponderal Index, respectively, and serum IGF-II in men, 
      i.e. the mean regression coefficients were -49.41 (95% CI: -87.06-11.77) 
      (microg/l)/kg and -3.49 (95% CI: -6.73-0.25) (microg/l)/(kg/m3), respectively. 
      Furthermore, in men birth weight was negatively associated with the (IGF-I + 
      IGF-II)/IGFBP-3 and IGF-II/IGFBP-3 ratios, which are believed to be indicators of 
      bioavailable IGF and IGF-II, respectively. However, no other associations were 
      found in any of the models. Between 1 and 16% of the variance in serum IGF-I, 
      IGF-II, and IGFBP-3, respectively, could be explained by the statistical models 
      used in the analyses. We found very little support to the hypothesis of an 
      association between fetal growth and the IGF axis throughout life.
FAU - Johnsen, S P
AU  - Johnsen SP
AD  - Department of Clinical Epidemiology, Aarhus University Hospital and Aalborg 
      Hospital, Aarhus, Denmark. spj@soci.au.dk
FAU - Sorensen, H T
AU  - Sorensen HT
FAU - Thomsen, J L
AU  - Thomsen JL
FAU - Gronbaek, H
AU  - Gronbaek H
FAU - Flyvbjerg, A
AU  - Flyvbjerg A
FAU - Engberg, M
AU  - Engberg M
FAU - Lauritzen, T
AU  - Lauritzen T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Aged
MH  - Biomarkers/*analysis
MH  - Birth Weight/physiology
MH  - Body Height/physiology
MH  - Cardiovascular Diseases/immunology
MH  - Denmark
MH  - Embryonic and Fetal Development/immunology/*physiology
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Insulin-Like Growth Factor II/*analysis
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/immunology
EDAT- 2004/03/12 05:00
MHDA- 2004/07/01 05:00
CRDT- 2004/03/12 05:00
PHST- 2004/03/12 05:00 [pubmed]
PHST- 2004/07/01 05:00 [medline]
PHST- 2004/03/12 05:00 [entrez]
AID - 10.1023/b:ejep.0000013396.40006.8f [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2004;19(1):41-7. doi: 10.1023/b:ejep.0000013396.40006.8f.