PMID- 15013059
OWN - NLM
STAT- MEDLINE
DCOM- 20040413
LR  - 20061115
IS  - 0920-1211 (Print)
IS  - 0920-1211 (Linking)
VI  - 57
IP  - 2-3
DP  - 2003 Dec
TI  - Lipopolysaccharide retards development of amygdala kindling but does not affect 
      fully-kindled seizures in rats.
PG  - 175-80
AB  - Seizures are common sequel to brain insults in cases such as stroke, trauma and 
      infection where there is a certain neuroinflammation. Intracerebroventricular 
      (i.c.v.) administration of lipopolysaccharide (LPS) induces an inflammatory state 
      in brain that is used as a model of neuroinflammation. We studied the effect of 
      LPS (0.25 and 2.5 microg/rat, i.c.v.) on development of electrical kindling of 
      the amygdala and on fully-kindled seizures. LPS, at the doses used, had no effect 
      on fully-kindled seizures and afterdischarge (AD) duration at 0.5, 2 or 4h after 
      administration. However, daily injection of LPS (2.5 microg/rat) retarded 
      acquisition of kindled behavioral seizures. This antiepileptogenic effect could 
      be due to the release of inflammatory mediators from microglia and the related 
      morphological and functional changes in synaptic neurotransmission.
FAU - Sayyah, Mohammad
AU  - Sayyah M
AD  - Department of Physiology and Pharmacology, Institute Pasteur of Iran, Pasteur 
      Avenue, Tehran 13164, Iran. sayyah@institute.pasteur.ac.ir
FAU - Najafabadi, Iraj Toubeihaye
AU  - Najafabadi IT
FAU - Beheshti, Siamak
AU  - Beheshti S
FAU - Majzoob, Sayeh
AU  - Majzoob S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Amygdala/*drug effects/physiology
MH  - Animals
MH  - Kindling, Neurologic/*drug effects/physiology
MH  - Lipopolysaccharides/*administration & dosage
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Seizures/physiopathology/*prevention & control
EDAT- 2004/03/12 05:00
MHDA- 2004/04/14 05:00
CRDT- 2004/03/12 05:00
PHST- 2003/09/18 00:00 [received]
PHST- 2003/11/10 00:00 [revised]
PHST- 2003/11/26 00:00 [accepted]
PHST- 2004/03/12 05:00 [pubmed]
PHST- 2004/04/14 05:00 [medline]
PHST- 2004/03/12 05:00 [entrez]
AID - S0920121103002286 [pii]
AID - 10.1016/j.eplepsyres.2003.11.002 [doi]
PST - ppublish
SO  - Epilepsy Res. 2003 Dec;57(2-3):175-80. doi: 10.1016/j.eplepsyres.2003.11.002.