PMID- 15015591
OWN - NLM
STAT- MEDLINE
DCOM- 20040521
LR  - 20041117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 24
IP  - 1
DP  - 2004 Jan-Feb
TI  - Numerical aberrations of chromosome 8 in gastric cancer detected by fluorescence 
      in situ hybridization.
PG  - 155-9
AB  - BACKGROUND: Limited data are available on the genetic events underlying gastric 
      cancer. Studying a few cases by conventional cytogenetic techniques, we 
      previously reported that chromosome 8 might be frequently involved. The aim of 
      our study was to evaluate the numerical aberrations of chromosome 8 in gastric 
      cancer using fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: 
      FISH, with an a-satellite DNA probe specific for chromosome 8, was applied to 37 
      primary gastric tumors directly processed for cytogenetic study. RESULTS: 
      Numerical aberrations of chromosome 8 were observed in 23 out of 37 tumors 
      (62.16%). Trisomy was detected in 16 cases (43.24%), tetrasomy in 4 cases 
      (10.81%) and monosomy in 3 cases (8.10%). No correlation was found between 
      polysomy 8 and the histopathologic characteristics of the tumors. CONCLUSION: An 
      increase in the number of chromosome 8 may frequently occur in gastric cancer. 
      Advanced and more aggressive gastric tumors did not harbor polysomy 8. Further 
      studies at molecular and clinical level must be carried out to identify the gene 
      alterations reflected by polysomy 8 and possibly to facilitate the detection of 
      specific tumors subtypes.
FAU - Panani, Anna D
AU  - Panani AD
AD  - The Second Department of Internal Medicine Propaedeutic, Research Unit, Athens 
      University, Evangelismos Hospital, Athens, Greece. apanani@med.uoa.gr
FAU - Ferti, Angeliki D
AU  - Ferti AD
FAU - Avgerinos, Alexandros
AU  - Avgerinos A
FAU - Raptis, Satirios A
AU  - Raptis SA
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Stomach Neoplasms/*genetics/pathology
EDAT- 2004/03/16 05:00
MHDA- 2004/05/22 05:00
CRDT- 2004/03/16 05:00
PHST- 2004/03/16 05:00 [pubmed]
PHST- 2004/05/22 05:00 [medline]
PHST- 2004/03/16 05:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2004 Jan-Feb;24(1):155-9.