PMID- 15016191
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20040630
LR  - 20040312
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 2
IP  - 3
DP  - 2001 Sep
TI  - HLA class II genetic association of type 1 diabetes mellitus in Czech children.
PG  - 98-102
AB  - To examine human leukocyte antigen (HLA) class II association of type 1 diabetes 
      mellitus (DM) in Czech children, we performed a case-control study of 261 
      patients diagnosed before the age of 15 and 289 non-diabetic control children. 
      Complete HLA-DQA1, DQB1 genotyping and DRB1*04 subtyping were carried out by 
      polymerase chain reactions with sequence-specific primers. The effect of the 
      DRB1*04 subtypes was studied in DRB1*04 alleles carried on DQB1*0302-DQA1*03 
      haplotypes. The risk was statistically evaluated by testing 2 x 2 tables, 
      considering corrected p-values < 0.05 significant. The DQB1*0302 (odds ratio, OR 
      = 9.0), DQB1*0201 (OR = 3.4) and DQA1*03 (OR = 7.5) alleles were significantly 
      associated with diabetes risk, while the DQB1*0602 (OR = 0.02), DQB1*0301 (OR = 
      0.08), DQB1*0503 (OR = 0.13), DQB1*0603 (OR = 0.20), DQA1*01 (OR = 0.28) and 
      DQA1*02 (OR = 0.26) alleles were significantly protective. Of the DQA1-DQB1 
      genotypes, we point out the extremely high risk of OR = 116 conferred by 
      HLA-DQA1*05-DQB1*0201/DQA1*03-DQB1*0302. Among DRB1*04 subtypes, DRB1*0403 was 
      significantly protective (OR = 0.05, CI 95% 0.01-0.45). Since none of the 
      remaining DRB1*04 subtypes was associated with type 1 DM, our study may present 
      another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify 
      type 1 diabetes risk generally in European populations.
FAU - Cinek, O
AU  - Cinek O
AD  - 2nd Department of Pediatrics, 2nd Medical School of Charles University, 
      Prague-Motol, Czech Republic. Ondrej.Cinek@Lfmotol.cuni.cz
FAU - Kolouskova, S
AU  - Kolouskova S
FAU - Snajderova, M
AU  - Snajderova M
FAU - Sumnik, Z
AU  - Sumnik Z
FAU - Sedlakova, P
AU  - Sedlakova P
FAU - Drevinek, P
AU  - Drevinek P
FAU - Vavrinec, J
AU  - Vavrinec J
FAU - Ronningen, K S
AU  - Ronningen KS
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
EDAT- 2004/03/16 05:00
MHDA- 2004/03/16 05:01
CRDT- 2004/03/16 05:00
PHST- 2004/03/16 05:00 [pubmed]
PHST- 2004/03/16 05:01 [medline]
PHST- 2004/03/16 05:00 [entrez]
AID - PDI020302 [pii]
AID - 10.1034/j.1399-5448.2001.002003098.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2001 Sep;2(3):98-102. doi: 
      10.1034/j.1399-5448.2001.002003098.x.