PMID- 15017311
OWN - NLM
STAT- MEDLINE
DCOM- 20040504
LR  - 20220408
IS  - 1056-6163 (Print)
IS  - 1056-6163 (Linking)
VI  - 13
IP  - 1
DP  - 2004 Mar
TI  - Early failure of dental implants and TNF-alpha (G-308A) gene polymorphism.
PG  - 95-101
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a potent inflammatory mediator with 
      bone resorption activity. Polymorphisms in the promoter region of the human 
      TNF-alpha gene have been shown to affect the levels of this cytokine and have 
      been associated with a variety of diseases. The aim of this study was to 
      investigate the possible relationship between early implant failure and a single 
      nucleotide polymorphism (SNP) in the -308 promoter region of the TNF-alpha gene. 
      A sample of 66 nonsmokers was divided into 2 groups: a test group comprising 28 
      patients (mean age, 52.7 years) with one or more early failed implants and a 
      control group consisting of 38 individuals (mean age, 43.2 years) with one or 
      more healthy implants. Genomic DNA from buccal mucosa was amplified by the 
      polymerase chain reaction (PCR), analyzed by restriction fragment length 
      polymorphism (RFLP), and submitted to polyacrylamide gel electrophoresis to 
      distinguish allele G and allele A of the TNF-alpha (-308) gene polymorphism. 
      Differences in the allele and genotype frequencies between control and test 
      groups were assessed by chi-squared test (P <0.05). No significant difference was 
      observed in the allele (P = 0.4635) and genotype (P = 0.4445) distribution of the 
      polymorphism when control and failure groups were compared. The results indicate 
      that the TNF-alpha (G-308A) gene polymorphism is not associated with early 
      implant failure, suggesting that its presence alone does not constitute a genetic 
      risk factor for implant loss in the Brazilian population.
FAU - Campos, Maria Isabela Guimaraes
AU  - Campos MI
AD  - Department of Morphology, Dental School of Piracicaba, State University of 
      Campinas, Piracicaba, SP, Brazil.
FAU - dos Santos, Maria Cristina Leme Godoy
AU  - dos Santos MC
FAU - Trevilatto, Paula Cristina
AU  - Trevilatto PC
FAU - Scarel-Caminaga, Raquel Mantuaneli
AU  - Scarel-Caminaga RM
FAU - Bezerra, Fabio Jose Barbosa
AU  - Bezerra FJ
FAU - Line, Sergio Roberto Peres
AU  - Line SR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Implant Dent
JT  - Implant dentistry
JID - 9206481
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 5Z93L87A1R (Guanine)
RN  - 9007-49-2 (DNA)
RN  - JAC85A2161 (Adenine)
MH  - Adenine
MH  - Adult
MH  - Alleles
MH  - Chi-Square Distribution
MH  - DNA/genetics
MH  - *Dental Restoration Failure
MH  - Female
MH  - Genotype
MH  - Guanine
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/genetics
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2004/03/17 05:00
MHDA- 2004/05/05 05:00
CRDT- 2004/03/17 05:00
PHST- 2004/03/17 05:00 [pubmed]
PHST- 2004/05/05 05:00 [medline]
PHST- 2004/03/17 05:00 [entrez]
AID - 00008505-200413010-00019 [pii]
AID - 10.1097/01.id.0000116458.60585.c4 [doi]
PST - ppublish
SO  - Implant Dent. 2004 Mar;13(1):95-101. doi: 10.1097/01.id.0000116458.60585.c4.