PMID- 15017582
OWN - NLM
STAT- MEDLINE
DCOM- 20040414
LR  - 20220223
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 35
IP  - 3
DP  - 2004 Mar
TI  - Colocalization and alteration of estrogen receptor-alpha and -beta in the 
      hippocampus in Alzheimer's disease.
PG  - 275-80
AB  - The human hippocampus is severely affected in Alzheimer's disease (AD). Because 
      postmenopausal estrogen use may decrease the risk and delay the onset and 
      progression of AD, possibly by a direct action on the hippocampal neurons, we 
      used fluorescence immunocytochemistry to examine the colocalization of estrogen 
      receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) in the hippocampus 
      of elderly human controls and AD patients. Double-labeling cells (DLCs) of 
      ERalpha and ERbeta can be divided into 3 types: double-cytoplasm-staining cells 
      (DCCs), double-nucleus-staining cells (DNCs), and ERalpha nucleus-staining and 
      ERbeta cytoplasm-staining cells (NCCs). There was no difference in the percentage 
      of DLCs in total ERalpha-positive cells or in total ERbeta-positive cells in the 
      CA1 to CA4 subfields of the hippocampus between controls and AD patients. 
      Interestingly, the ratio of DNCs to the total ERalpha-positive cells (2.6% +/- 
      0.5%) or to the total ERbeta-positive cells (1.8% +/- 0.3%) in the CA1 subfield 
      of the AD hippocampus was significantly decreased in comparison with controls 
      (5.0% +/- 0.7% and 3.9% +/- 0.6%, respectively; P<0.001), suggesting that changes 
      in the compartmentalization of these receptors could play a role in the 
      pathogenesis of AD.
FAU - Lu, Ya-Ping
AU  - Lu YP
AD  - Department of Neurobiology, Life Sciences School, University of Science and 
      Technology of China, Hefei, China.
FAU - Zeng, Mei
AU  - Zeng M
FAU - Swaab, Dick F
AU  - Swaab DF
FAU - Ravid, Rivka
AU  - Ravid R
FAU - Zhou, Jiang-Ning
AU  - Zhou JN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
SB  - IM
CIN - Hum Pathol. 2004 Mar;35(3):271-4. PMID: 15017581
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*metabolism/pathology
MH  - Cell Count
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Hippocampus/*metabolism/pathology
MH  - Humans
MH  - Middle Aged
MH  - Neurons/metabolism/pathology
MH  - Receptors, Estrogen/*metabolism
EDAT- 2004/03/16 05:00
MHDA- 2004/04/15 05:00
CRDT- 2004/03/16 05:00
PHST- 2004/03/16 05:00 [pubmed]
PHST- 2004/04/15 05:00 [medline]
PHST- 2004/03/16 05:00 [entrez]
AID - S0046817703006592 [pii]
AID - 10.1016/j.humpath.2003.11.004 [doi]
PST - ppublish
SO  - Hum Pathol. 2004 Mar;35(3):275-80. doi: 10.1016/j.humpath.2003.11.004.