PMID- 15022060
OWN - NLM
STAT- MEDLINE
DCOM- 20041215
LR  - 20060508
IS  - 1093-5266 (Print)
IS  - 1093-5266 (Linking)
VI  - 7
IP  - 2
DP  - 2004 Mar-Apr
TI  - Cytogenetic distinction among benign fibro-osseous lesions of bone in children 
      and adolescents: value of karyotypic findings in differential diagnosis.
PG  - 148-58
AB  - Benign fibro-osseous lesions of bone (BFOL) comprise a group of clinically 
      distinct entities with significant histologic overlap and often occur in children 
      and adolescents. Because of prior studies indicating that these lesions possess 
      distinct karyotypic abnormalities, we conducted a retrospective review of 
      cytogenetic analyses performed in a series of 16 BFOL in children and adolescents 
      diagnosed at two institutions. These comprised five cases with the diagnosis of 
      ossifying fibroma, four with osteofibrous dysplasia, and seven with fibrous 
      dysplasia arising in the skeleton of 16 children and adolescents. All cases were 
      analyzed using standard G-banding techniques on fresh tumors explanted in tissue 
      culture media. Spectral karyotyping (SKY) and fluorescence in situ hybridization 
      (FISH) were used to analyze selected metaphases of a talar lesion with the 
      histologic features of ossifying fibroma. All four confirmed ossifying fibromas, 
      including the talar lesion, contained clonal aberrations fusing breakpoints on 
      Xq26 and 2q33, and one case with dissimilar histology did not. Three of four 
      osteofibrous dysplasias contained multiple copies of chromosomes 8, 12, and/or 
      21. All but two fibrous dysplasia cases exhibited either a completely normal 
      karyotype or single cell aberrations. One fibrous dysplasia had subtle 
      chromosomal abnormalities not seen in other cases in the series, and another had 
      complex abnormalities involving multiple chromosomes. Our current and published 
      results indicate that cytogenetics might be of ancillary use in the diagnosis of 
      BFOL and that a characteristic chromosomal arrangement is associated with 
      ossifying fibroma.
FAU - Parham, David M
AU  - Parham DM
AD  - Department of Pathology, Arkansas Children Hospital and University of Arkansas 
      for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA. 
      parhamdavidm@uams.edu
FAU - Bridge, Julia A
AU  - Bridge JA
FAU - Lukacs, Janet L
AU  - Lukacs JL
FAU - Ding, Yiling
AU  - Ding Y
FAU - Tryka, A Francine
AU  - Tryka AF
FAU - Sawyer, Jeffrey R
AU  - Sawyer JR
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20040317
PL  - United States
TA  - Pediatr Dev Pathol
JT  - Pediatric and developmental pathology : the official journal of the Society for 
      Pediatric Pathology and the Paediatric Pathology Society
JID - 9809673
SB  - IM
CIN - Pediatr Dev Pathol. 2004 Mar-Apr;7(2):105. PMID: 15181660
MH  - Adolescent
MH  - Adult
MH  - Bone Neoplasms/*genetics/pathology
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Diagnosis, Differential
MH  - Female
MH  - Fibroma, Ossifying/*genetics
MH  - Fibrous Dysplasia of Bone/*genetics/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Retrospective Studies
MH  - Spectral Karyotyping
EDAT- 2004/03/17 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/03/17 05:00
PHST- 2003/06/11 00:00 [received]
PHST- 2003/11/13 00:00 [accepted]
PHST- 2004/03/17 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/03/17 05:00 [entrez]
AID - 10.1007/s10024-003-6065-z [doi]
PST - ppublish
SO  - Pediatr Dev Pathol. 2004 Mar-Apr;7(2):148-58. doi: 10.1007/s10024-003-6065-z. 
      Epub 2004 Mar 17.