PMID- 15022128 OWN - NLM STAT- MEDLINE DCOM- 20040713 LR - 20191220 IS - 8755-6863 (Print) IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 37 IP - 4 DP - 2004 Apr TI - Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. PG - 318-23 AB - We compared three methods of reporting maximal expiratory flow (V'maxFRC) measured in partial expiratory flow-volume curves (PEFVCs) at the point of functional residual capacity (FRC). PEFVCs were obtained with the rapid thoracoabdominal compression technique (RTC) on a total of 446 occasions in 281 HIV-negative, asymptomatic infants (4.8-28.1 months old). Three different expressions of V'maxFRC were recorded: 1) the highest measured flow (maxV'FRC), 2) the mean of the three highest flows (mean3V'FRC), and 3) the flow at FRC in a composite curve (compV'FRC) consisting of PEFVCs, obtained at different jacket pressures and superimposed at their distal limb. The numerical value of maxV'FRC was 7.4% (+/-5.6%) higher than the mean3V'FRC, and 11.9% (+/-17.7%) higher than the compV'FRC; the mean3V'FRC was 5% (+/-18.3%) higher than the compV'FRC. Bland-Altman analysis was used to evaluate the agreement between the three indices. The mean difference and 95% limits of agreement were: maxV'FRC -mean3V'FRC, 14 +/- 18 ml/sec; maxV'FRC - compV'(FRC), 23 +/- 58 ml/sec; and mean3V'(FRC) - compV'(FRC), 10 +/- 52 ml/sec. The differences between the slopes of the three indices (regressed against height) were statistically significant, although clinically unimportant. We conclude that despite their high correlation, the mean3V'FRC and maxV'FRC should not be used interchangeably, and that the composite analysis, although useful, does not improve the reproducibility of V'maxFRC, and thus it cannot be recommended for routine use in its current form. CI - Copyright 2004 Wiely-Liss, Inc. FAU - Koumbourlis, Anastassios C AU - Koumbourlis AC AD - Pediatric Pulmonary Division, Columbia-Presbyterian Medical Center, New York, New York, USA. akoumbou@LIJ.edu FAU - Chen, Xin C AU - Chen XC FAU - Rao, J Sunil AU - Rao JS FAU - Schluchter, Mark D AU - Schluchter MD FAU - Easley, Kirk AU - Easley K FAU - Colin, Andrew A AU - Colin AA FAU - Hiatt, Peter AU - Hiatt P FAU - Kattan, Meyer AU - Kattan M FAU - McCarthy, Kevin AU - McCarthy K FAU - Mellins, Robert B AU - Mellins RB FAU - Peavy, Hannah AU - Peavy H FAU - Platzker, Arnold C G AU - Platzker AC FAU - Steinbach, Suzanne AU - Steinbach S FAU - Ting, Andrew AU - Ting A FAU - Weisner, Michael D AU - Weisner MD FAU - Wohl, Mary Ellen B AU - Wohl ME CN - Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodificiency Virus (P2C2HIV) Study Group CN - National Heart, Lung and Blood Institute LA - eng GR - K01 RR000188/RR/NCRR NIH HHS/United States GR - M01 RR000645/RR/NCRR NIH HHS/United States GR - RR-00043/RR/NCRR NIH HHS/United States GR - N01-HR-96039/HR/NHLBI NIH HHS/United States GR - RR-0071/RR/NCRR NIH HHS/United States GR - N01-HR-96040/HR/NHLBI NIH HHS/United States GR - M01 RR000533/RR/NCRR NIH HHS/United States GR - N01 HR096037/HR/NHLBI NIH HHS/United States GR - M01 RR002172/RR/NCRR NIH HHS/United States GR - M01 RR000188/RR/NCRR NIH HHS/United States GR - M01 RR000071/RR/NCRR NIH HHS/United States GR - N01-HR-96043/HR/NHLBI NIH HHS/United States GR - RR-00188/RR/NCRR NIH HHS/United States GR - RR-00685/RR/NCRR NIH HHS/United States GR - RR-02172/RR/NCRR NIH HHS/United States GR - RR-00533/RR/NCRR NIH HHS/United States GR - RR-00645/RR/NCRR NIH HHS/United States GR - M01 RR000043/RR/NCRR NIH HHS/United States GR - N01-HR-96042/HR/NHLBI NIH HHS/United States GR - N01-HR-96038/HR/NHLBI NIH HHS/United States GR - N01-HR-96041/HR/NHLBI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Child, Preschool MH - Databases as Topic MH - Female MH - Functional Residual Capacity/physiology MH - Humans MH - Infant MH - Male MH - Maximal Expiratory Flow Rate/*physiology MH - Maximal Expiratory Flow-Volume Curves/*physiology MH - Prospective Studies MH - Reference Values MH - Regression Analysis PMC - PMC4410185 MID - NIHMS682484 EDAT- 2004/03/17 05:00 MHDA- 2004/07/14 05:00 PMCR- 2015/04/27 CRDT- 2004/03/17 05:00 PHST- 2004/03/17 05:00 [pubmed] PHST- 2004/07/14 05:00 [medline] PHST- 2004/03/17 05:00 [entrez] PHST- 2015/04/27 00:00 [pmc-release] AID - 10.1002/ppul.10452 [doi] PST - ppublish SO - Pediatr Pulmonol. 2004 Apr;37(4):318-23. doi: 10.1002/ppul.10452.