PMID- 15022720
OWN - NLM
STAT- MEDLINE
DCOM- 20040928
LR  - 20190917
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 27
IP  - 2
DP  - 2004 Feb
TI  - Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis 
      on carbon tetrachloride-induced hepatic injury in rats.
PG  - 184-8
AB  - The present study was carried out to clarify whether tectorigenin and tectoridin 
      isolated from the rhizomes of Belamcanda chinensis (Iridaceae) inhibit hepatic 
      damage induced by carbon tetrachloride (CCl4)-intoxication in rats by the 
      experimental methods in vitro and in vivo. Tectorigenin and tectoridin exhibited 
      a significant decrease in serum transaminase activities elevated by hepatic 
      damage induced by CCl4-intoxication in rats, as well as in a lipid peroxidation 
      causing a significant decrease in malondialdehyde (MDA) production by 
      thiobarbituric acid (TBA)-reactant assay. Both compounds also showed strong 
      increase in the antioxidant enzymes such as hepatic cytosolic superoxide 
      dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in 
      CCl4-intoxicated rats. These results suggested that tectorigenin and tectoridin 
      isolated from the rhizomes of B. chinensis possess not only the antioxidative, 
      but also the hepatoprotective activities in CCl4-intoxicated rats.
FAU - Jung, Sang Hoon
AU  - Jung SH
AD  - Natural Products Research Institute, College of Pharmacy, Seoul National 
      University, Seoul 110-460, Korea.
FAU - Lee, Yeon Sil
AU  - Lee YS
FAU - Lim, Soon Sung
AU  - Lim SS
FAU - Lee, Sanghyun
AU  - Lee S
FAU - Shin, Kuk Hyun
AU  - Shin KH
FAU - Kim, Yeong Shik
AU  - Kim YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Antioxidants)
RN  - 0 (Isoflavones)
RN  - 0 (Plant Extracts)
RN  - 855130H9CO (tectorigenin)
RN  - 968X515NZH (tectoridin)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Aspartate Aminotransferases/blood
MH  - Carbon Tetrachloride Poisoning/*drug therapy/pathology
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/pathology
MH  - Cytosol/metabolism
MH  - Iridaceae/*chemistry
MH  - Isoflavones/pharmacology/*therapeutic use
MH  - Lipid Peroxidation/drug effects
MH  - Liver/metabolism/pathology
MH  - Male
MH  - Plant Extracts/chemistry/pharmacology
MH  - Plant Roots/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Superoxide Dismutase/metabolism
EDAT- 2004/03/17 05:00
MHDA- 2004/09/29 05:00
CRDT- 2004/03/17 05:00
PHST- 2004/03/17 05:00 [pubmed]
PHST- 2004/09/29 05:00 [medline]
PHST- 2004/03/17 05:00 [entrez]
AID - 10.1007/BF02980104 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2004 Feb;27(2):184-8. doi: 10.1007/BF02980104.