PMID- 15023048
OWN - NLM
STAT- MEDLINE
DCOM- 20040402
LR  - 20220311
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 121
IP  - 3
DP  - 2004 Mar
TI  - Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and 
      autoantibodies to oxLig-1/beta2-glycoprotein I in patients with systemic lupus 
      erythematosus and antiphospholipid syndrome.
PG  - 426-36
AB  - Oxidized low-density lipoprotein (oxLDL) interacts with beta2-glycoprotein I 
      (beta2-GPI) via oxLDL-derived specific ligands (oxLig-1) forming complexes. The 
      prevalence and significance of oxLDL/alpha2-GPI complexes and antibodies to 
      oxLig-1/alpha2-GPI were evaluated in patients with systemic lupus erythematosus 
      (SLE) and antiphospholipid syndrome (APS). The oxLDL/beta2-GPI complex was 69% 
      positive (above mean + 3 SD of control subjects) in 97 consecutive patients with 
      SLE, 62% in 40 patients with SLE with secondary APS, and 60% in 50 control 
      patients with SLE without APS. IgG anti-oxLig-1/beta2-GPI antibody was positive 
      in 31 (32%) of 97 consecutive patients with SLE, in 26 (65%) of 40 patients with 
      SLE with secondary APS, and in 6 (19%) of 32 control patients with SLE. 
      Anti-oxLig-1/beta2-GPI antibodies were 93.7% specific with a positive predictive 
      value of 90.0% for APS, better than anticardiolipin antibodies (80.0% specific, 
      71.4% predictive value). These results confirm that oxLDL/beta2-GPI complexes are 
      common in SLE and suggest a possible immunogenic role in APS. In contrast, IgG 
      anti-oxLig-1/beta2-GPI antibodies not only are associated with but also are 
      clinically useful risk factors for APS.
FAU - Lopez, Daniel
AU  - Lopez D
AD  - Corgenix, Westminster, CO 80234, USA.
FAU - Garcia-Valladares, Ignacio
AU  - Garcia-Valladares I
FAU - Palafox-Sanchez, Claudia A
AU  - Palafox-Sanchez CA
FAU - De La Torre, Ignacio Garcia
AU  - De La Torre IG
FAU - Kobayashi, Kazuko
AU  - Kobayashi K
FAU - Matsuura, Eiji
AU  - Matsuura E
FAU - Lopez, Luis R
AU  - Lopez LR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Autoantibodies)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antiphospholipid Syndrome/blood/*immunology
MH  - Autoantibodies/blood/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycoproteins/*immunology/metabolism
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Lipoproteins, LDL/*immunology/metabolism
MH  - Lupus Erythematosus, Systemic/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Time Factors
MH  - beta 2-Glycoprotein I
EDAT- 2004/03/17 05:00
MHDA- 2004/04/03 05:00
CRDT- 2004/03/17 05:00
PHST- 2004/03/17 05:00 [pubmed]
PHST- 2004/04/03 05:00 [medline]
PHST- 2004/03/17 05:00 [entrez]
AID - 10.1309/2AUE-6HD4-W6TL-EUU5 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2004 Mar;121(3):426-36. doi: 10.1309/2AUE-6HD4-W6TL-EUU5.