PMID- 15023138 OWN - NLM STAT- MEDLINE DCOM- 20041109 LR - 20230124 IS - 1600-6135 (Print) IS - 1600-6135 (Linking) VI - 4 IP - 4 DP - 2004 Apr TI - Acute graft versus host disease following liver transplantation: the enemy within. PG - 466-74 AB - This article reviews acute graft vs. host disease (GVHD) as a complication of orthotopic liver transplantation (OLT). The incidence, presentation, clinical course and outcome of GVHD after OLT are summarized and the pathogenesis is discussed, drawing parallels with GVHD after allogeneic haematopoietic stem cell transplantation. Risk factors for GVHD after OLT are examined and the potential role of donor lymphocyte macrochimerism in the recipient peripheral blood as a diagnostic aid for GVHD is discussed. Finally, treatment of GVHD after OLT is reviewed with particular emphasis on the potential role of some of the newer biological agents. FAU - Taylor, Anna L AU - Taylor AL AD - Department of Surgery, University of Cambridge School of Clinical Medicine, Cambridge, UK. FAU - Gibbs, Paul AU - Gibbs P FAU - Bradley, J Andrew AU - Bradley JA LA - eng PT - Journal Article PT - Review PL - United States TA - Am J Transplant JT - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JID - 100968638 RN - 0 (Immunosuppressive Agents) SB - IM MH - Age Factors MH - Animals MH - Graft vs Host Disease/*pathology/*prevention & control MH - Hematopoietic Stem Cell Transplantation/methods MH - Humans MH - Immunosuppressive Agents/therapeutic use MH - Liver Transplantation/adverse effects/*methods MH - Models, Biological MH - Phenotype MH - Risk Factors MH - Transplantation Chimera MH - Transplantation, Homologous/methods RF - 74 EDAT- 2004/03/17 05:00 MHDA- 2004/11/13 09:00 CRDT- 2004/03/17 05:00 PHST- 2004/03/17 05:00 [pubmed] PHST- 2004/11/13 09:00 [medline] PHST- 2004/03/17 05:00 [entrez] AID - S1600-6135(22)07493-7 [pii] AID - 10.1111/j.1600-6143.2004.00406.x [doi] PST - ppublish SO - Am J Transplant. 2004 Apr;4(4):466-74. doi: 10.1111/j.1600-6143.2004.00406.x.