PMID- 15023145
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 4
IP  - 4
DP  - 2004 Apr
TI  - Immune regulation and graft survival in kidney transplant recipients are both 
      enhanced by human leukocyte antigen matching.
PG  - 537-43
AB  - We hypothesized that donor/recipient sharing of the human leukocyte antigen (HLA) 
      involved in allopeptide presentation to the T regulatory cell increases the 
      incidence of immune regulation, thus contributing to long-term graft survival. 
      Peripheral blood mononuclear cells (PBMC) were obtained from 40 living related 
      donor (LRD) and 31 cadaver renal transplant recipients. The trans vivo delayed 
      type hypersensitivity (DTH) assay was used to assign patients to regulator, 
      nonregulator, and sensitized categories. In a large cohort (n=1934 patients), 
      primary graft survival and rejection episodes were analyzed using a log rank test 
      for comparison with the DTH results. The highest incidence of regulated 
      anti-donor DTH was observed in the LRD HLA-identical group (6/6; 100%) followed 
      by the LRD HLA 1 haplotype matched group (18/27; 67%). Within the cadaver 
      population, two DR-matched recipients had a higher frequency of regulated 
      anti-donor DTH (6/11; 55%) than 1 & 0 DR-matched recipients (3/18; 17%). In a 
      multivariate model, matching for HLA-DR alone, or for DR plus DQ was 
      significantly (p=0.045, p=0.041) correlated with DTH regulation. The better 
      HLA-matched groups showed the highest incidence of DTH regulation and, in a 
      larger retrospective analysis, displayed better graft survival and freedom from 
      acute rejection (p<0.0001). HLA matching, and HLA-DR matching in particular, 
      correlates with the incidence of immune regulation after kidney transplantation.
FAU - Rodriguez, Daniel S
AU  - Rodriguez DS
AD  - Department of Surgery, University of Wisconsin, Madison, WI, USA.
FAU - Jankowska-Gan, Ewa
AU  - Jankowska-Gan E
FAU - Haynes, Lynn D
AU  - Haynes LD
FAU - Leverson, Glenn
AU  - Leverson G
FAU - Munoz, Alejandro
AU  - Munoz A
FAU - Heisey, Dennis
AU  - Heisey D
FAU - Sollinger, Hans W
AU  - Sollinger HW
FAU - Burlingham, William J
AU  - Burlingham WJ
LA  - eng
GR  - R01-AI-44077/AI/NIAID NIH HHS/United States
GR  - R21-AI-49900/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Am J Transplant. 2004 Oct;4(10):1725-6. PMID: 15367233
MH  - Adult
MH  - Animals
MH  - Cadaver
MH  - Cohort Studies
MH  - Female
MH  - *Graft Survival
MH  - HLA Antigens/*chemistry
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Kidney Transplantation/*immunology/*methods
MH  - Leukocytes, Mononuclear/metabolism
MH  - Living Donors
MH  - Male
MH  - Mice
MH  - Mice, SCID
MH  - Middle Aged
MH  - Phenotype
MH  - T-Lymphocytes/immunology
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2004/03/17 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/03/17 05:00
PHST- 2004/03/17 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/03/17 05:00 [entrez]
AID - S1600-6135(22)07499-8 [pii]
AID - 10.1111/j.1600-6143.2004.00385.x [doi]
PST - ppublish
SO  - Am J Transplant. 2004 Apr;4(4):537-43. doi: 10.1111/j.1600-6143.2004.00385.x.