PMID- 15023359
OWN - NLM
STAT- MEDLINE
DCOM- 20040505
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1697
IP  - 1-2
DP  - 2004 Mar 11
TI  - The UL97 protein kinase of human cytomegalovirus and homologues in other 
      herpesviruses: impact on virus and host.
PG  - 169-80
AB  - The human herpesviruses, herpes simplex virus 1 (HSV-1), HSV-2, varicella zoster 
      virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human 
      herpesvirus 6A (HHV-6A), HHV-6B, HHV-7 and HHV-8, establish persistent infections 
      with possible recurrence during immunosuppression. HCMV replication is inhibited 
      by the nucleoside analogue ganciclovir (GCV), the compound of choice for the 
      treatment of HCMV diseases and preemptive treatment of infections. The viral UL97 
      protein (pUL97) which shares homologies with protein kinases and bacterial 
      phosphotransferases is able to monophosphorylate GCV. Homologues of pUL97 are 
      found in HSV (UL13), VZV (ORF47), EBV (BGLF4), HHV-6 (U69), HHV-8 (ORF36) as well 
      as in murine CMV (M97) or rat CMV (R97). Several indolocarbazoles have been 
      reported to be specific inhibitors of pUL97. The protein is important for 
      efficient replication of the virus. Autophosphorylation of pUL97 was observed 
      using different experimental systems. Most recently, it has been shown that pUL97 
      interacts with the DNA polymerase processivity factor pUL44. Indolocarbazole 
      protein kinase inhibitors are promising lead compounds for the development of 
      more specific inhibitors of HCMV.
FAU - Michel, Detlef
AU  - Michel D
AD  - Universitatsklinikum Ulm, Abteilung Virologie, Albert-Einstein-Allee 11, 89081 
      Ulm, Germany. detlef.michel@medizin.uni-ulm.de
FAU - Mertens, Thomas
AU  - Mertens T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Antiviral Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.1.- (ganciclovir kinase)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/chemistry/pharmacology
MH  - Clinical Trials as Topic
MH  - Cytomegalovirus/drug effects/*enzymology
MH  - Enzyme Inhibitors/chemistry/pharmacology
MH  - Herpesviridae/drug effects/*enzymology
MH  - Humans
MH  - Phosphotransferases (Alcohol Group Acceptor)/*antagonists & 
      inhibitors/genetics/*physiology
MH  - Virus Replication/drug effects
RF  - 126
EDAT- 2004/03/17 05:00
MHDA- 2004/05/07 05:00
CRDT- 2004/03/17 05:00
PHST- 2003/09/28 00:00 [received]
PHST- 2003/11/12 00:00 [accepted]
PHST- 2004/03/17 05:00 [pubmed]
PHST- 2004/05/07 05:00 [medline]
PHST- 2004/03/17 05:00 [entrez]
AID - S1570963903003741 [pii]
AID - 10.1016/j.bbapap.2003.11.022 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2004 Mar 11;1697(1-2):169-80. doi: 
      10.1016/j.bbapap.2003.11.022.