PMID- 15028369
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20220317
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 43
IP  - 6
DP  - 2004 Mar 17
TI  - Aortic elastic properties and left ventricular diastolic function in patients 
      with Adamantiades-Behcet's disease.
PG  - 1075-81
AB  - OBJECTIVES: We investigated whether Adamantiades-Behcet's disease (ABD) is 
      related to impaired aortic (Ao) elastic properties and left ventricular (LV) 
      function. BACKGROUND: Adamantiades-Behcet's disease is an inflammatory disorder 
      characterized by vasculitis leading to vascular complications and, rarely, 
      myocarditis. METHODS: We studied 82 patients with ABD (age: 40 +/- 12 years) and 
      24 normal control subjects by echocardiography. Abdominal Ao diameter (mm/m(2)) 
      and Ao elastic indexes--namely, Ao strain (%), distensibility (cm(2) x dyn(-1)x 
      10(-6)), stiffness index, and pressure strain modulus (Ep) (cm(2) x dyn(-1) x 
      10(-6))--were calculated from the echocardiographically derived thoracic Ao 
      diameters (mm/m(2)), and the measurement of pulse pressure obtained by cuff 
      sphygmomanometry. Isovolumic relaxation time (IVRT) (ms), deceleration time (DT) 
      (ms), and flow propagation velocity (FPV) (cm/s) were measured by Doppler 
      echocardiography to assess diastolic LV function. The duration of disease and 
      presence of vascular complications were noted. RESULTS: Patients versus control 
      subjects had increased Ao diameters (p < 0.01), lower mean Ao strain and 
      distensibility (4 vs. 9 and 1.4 vs. 3.4, respectively, p < 0.01), higher mean 
      aortic stiffness index and Ep (15.6 vs. 6 and 1.17 vs. 0.44, respectively, p < 
      0.01), and impaired IVRT and FPV (p < 0.01). Aortic function indexes were related 
      to the duration of disease (p < 0.01) and increased DT (p < 0.01). Deceleration 
      time >190 ms predicted vascular complications with 80% sensitivity and 71% 
      specificity (odds ratio 6.52 [confidence interval: 2.23 to 19.03]). CONCLUSION: 
      Aortic elastic properties and diastolic LV function are impaired in patients with 
      ABD and are interrelated. The link between diastolic LV dysfunction and vascular 
      complications suggests the presence of a common pathophysiologic pathway and 
      provides a possible marker of risk for vascular disease.
FAU - Ikonomidis, Ignatios
AU  - Ikonomidis I
AD  - Department of Clinical Therapeutics, University of Athens, Alexandra Hospital, 
      Perikleous 19, Nea Chalkidona, Athens 14343, Greece. ignoik@otenet.gr
FAU - Lekakis, John
AU  - Lekakis J
FAU - Stamatelopoulos, Kimon
AU  - Stamatelopoulos K
FAU - Markomihelakis, Nikolaos
AU  - Markomihelakis N
FAU - Kaklamanis, Phaedon G
AU  - Kaklamanis PG
FAU - Mavrikakis, Myron
AU  - Mavrikakis M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
EIN - J Am Coll Cardiol. 2007 Feb 6;49(5):630
MH  - Adult
MH  - Aged
MH  - Aorta, Thoracic/diagnostic imaging/*physiopathology
MH  - Arteriosclerosis/diagnostic imaging/*physiopathology
MH  - Behcet Syndrome/*physiopathology
MH  - Case-Control Studies
MH  - Diastole
MH  - Echocardiography, Doppler/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Ventricular Dysfunction, Left/diagnostic imaging/pathology/*physiopathology
EDAT- 2004/03/19 05:00
MHDA- 2004/04/07 05:00
CRDT- 2004/03/19 05:00
PHST- 2003/07/19 00:00 [received]
PHST- 2003/08/26 00:00 [revised]
PHST- 2003/10/06 00:00 [accepted]
PHST- 2004/03/19 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2004/03/19 05:00 [entrez]
AID - S073510970400018X [pii]
AID - 10.1016/j.jacc.2003.10.042 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2004 Mar 17;43(6):1075-81. doi: 10.1016/j.jacc.2003.10.042.