PMID- 15030236
OWN - NLM
STAT- MEDLINE
DCOM- 20040507
LR  - 20131121
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 52
IP  - 6
DP  - 2004 Mar 24
TI  - Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative 
      effects in hyperhomocysteinemia rats.
PG  - 1720-5
AB  - Antioxidative effects of Dioscorea alata (D. alata) were investigated in 
      hyperhomocysteinemia (HHcy) induced by methionine (Met) oral feeding (1 (g/kg of 
      BW)/day). HHcy rats were fed a standard laboratory chow supplemented without or 
      with freeze-dried D. alata powder at 1, 2.5, and 5 (g/kg of BW)/day, assigned as 
      Met, Met + D1, Met + D2, and Met + D3 groups, respectively. Twelve weeks after D. 
      alata feeding, plasma homocysteine levels (16.3-24.2 microM) were significantly 
      decreased compared to that of the Met group (34.1 +/- 9.9 microM) (p < 0.01), and 
      similar to the basal level (15.0 +/- 1.9 microM). Thrombin-induced platelet 
      aggregation (PA) of the Met + D2 and Met + D3 groups was significantly lower than 
      that of the Met group. Plasma malondialdehyde levels, an indicator of lipid 
      peroxidation, and hepatic reactive oxygen species, an indicator of oxidative 
      stress, of HHcy with D. alata feeding were significantly lower than that without 
      D. alata feeding. The hepatic catalase in the Met + D2 and Met + D3 groups was 
      significantly elevated compared to that in the Met group. D. alata feeding did 
      not significantly change hepatic superoxide dismutase, glutathione peroxidase, 
      and glutathione reductase, which were adaptively enhanced by Met feeding. The 
      decreased glutathione/glutathione disulfide ratio in the Met group was increased 
      after D. alata feeding. These results indicated that HHcy induced by Met could be 
      reversed by D. alata feeding. D. alata feeding exhibited its antioxidative 
      effects in HHcy including alleviating PA, lipid peroxidation, and oxidative 
      stress, but did not induce activity of antioxidant enzymes which had already 
      adaptively increased by HHcy.
FAU - Chang, Sue-Joan
AU  - Chang SJ
AD  - Department of Biology, National Cheng Kung University, Tainan, Taiwan. 
      sjchang@mail.ncku.edu.tw
FAU - Lee, Yi-Chun
AU  - Lee YC
FAU - Liu, Sin-Yie
AU  - Liu SY
FAU - Chang, Tso-Wei
AU  - Chang TW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antioxidants)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Antioxidants/*administration & dosage
MH  - *Diet
MH  - Dioscorea/*chemistry
MH  - Homocysteine/blood
MH  - Hyperhomocysteinemia/chemically induced/*therapy
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Methionine
MH  - Oxidative Stress/drug effects
MH  - Platelet Aggregation/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2004/03/20 05:00
MHDA- 2004/05/08 05:00
CRDT- 2004/03/20 05:00
PHST- 2004/03/20 05:00 [pubmed]
PHST- 2004/05/08 05:00 [medline]
PHST- 2004/03/20 05:00 [entrez]
AID - 10.1021/jf0345954 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2004 Mar 24;52(6):1720-5. doi: 10.1021/jf0345954.