PMID- 15030519
OWN - NLM
STAT- MEDLINE
DCOM- 20040608
LR  - 20181113
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 136
IP  - 1
DP  - 2004 Apr
TI  - Plasma inflammatory cytokines and chemokines in severe acute respiratory 
      syndrome.
PG  - 95-103
AB  - Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease 
      caused by a novel coronavirus, but its immunopathological mechanisms have not yet 
      been fully elucidated. We investigated changes in plasma T helper (Th) cell 
      cytokines, inflammatory cytokines and chemokines in 20 patients diagnosed with 
      SARS. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine 
      interferon (IFN)-gamma, inflammatory cytokines interleukin (IL)-1, IL-6 and IL-12 
      for at least 2 weeks after disease onset, but there was no significant elevation 
      of inflammatory cytokine tumour necrosis factor (TNF)-alpha, anti-inflammatory 
      cytokine IL-10, Th1 cytokine IL-2 and Th2 cytokine IL-4. The chemokine profile 
      demonstrated significant elevation of neutrophil chemokine IL-8, monocyte 
      chemoattractant protein-1 (MCP-1), and Th1 chemokine IFN-gamma-inducible 
      protein-10 (IP-10). Corticosteroid reduced significantly IL-8, MCP-1 and IP-10 
      concentrations from 5 to 8 days after treatment (all P < 0.001). Together, the 
      elevation of Th1 cytokine IFN-gamma, inflammatory cytokines IL-1, IL-6 and IL-12 
      and chemokines IL-8, MCP-1 and IP-10 confirmed the activation of Th1 
      cell-mediated immunity and hyperinnate inflammatory response in SARS through the 
      accumulation of monocytes/macrophages and neutrophils.
FAU - Wong, C K
AU  - Wong CK
AD  - Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of 
      Wales Hospital, Shatin, Hong Kong.
FAU - Lam, C W K
AU  - Lam CW
FAU - Wu, A K L
AU  - Wu AK
FAU - Ip, W K
AU  - Ip WK
FAU - Lee, N L S
AU  - Lee NL
FAU - Chan, I H S
AU  - Chan IH
FAU - Lit, L C W
AU  - Lit LC
FAU - Hui, D S C
AU  - Hui DS
FAU - Chan, M H M
AU  - Chan MH
FAU - Chung, S S C
AU  - Chung SS
FAU - Sung, J J Y
AU  - Sung JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Glucocorticoids)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
CIN - Clin Exp Immunol. 2004 Apr;136(1):11-2. PMID: 15030507
MH  - Adult
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Biomarkers/blood
MH  - Chemokines/*blood
MH  - Cytokines/blood
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Male
MH  - Methylprednisolone/therapeutic use
MH  - Middle Aged
MH  - Prospective Studies
MH  - Severe Acute Respiratory Syndrome/*blood/drug therapy
MH  - T-Lymphocytes, Helper-Inducer/immunology
PMC - PMC1808997
EDAT- 2004/03/20 05:00
MHDA- 2004/06/21 10:00
PMCR- 2005/04/01
CRDT- 2004/03/20 05:00
PHST- 2004/03/20 05:00 [pubmed]
PHST- 2004/06/21 10:00 [medline]
PHST- 2004/03/20 05:00 [entrez]
PHST- 2005/04/01 00:00 [pmc-release]
AID - CEI2415 [pii]
AID - 10.1111/j.1365-2249.2004.02415.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2004 Apr;136(1):95-103. doi: 10.1111/j.1365-2249.2004.02415.x.