PMID- 15031788
OWN - NLM
STAT- MEDLINE
DCOM- 20040513
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 7
DP  - 2004 Apr 1
TI  - HIV-specific cellular immune response is inversely correlated with disease 
      progression as defined by decline of CD4+ T cells in relation to HIV RNA load.
PG  - 1199-208
AB  - The average time between infection with human immunodeficiency virus (HIV) and 
      development of acquired immune deficiency syndrome is approximately 8 years. 
      However, progression rates vary widely, depending on several determinants, 
      including HIV-specific immunity, host genetic factors, and virulence of the 
      infecting strain. In untreated HIV-infected patients with different progression 
      rates, we examined HIV-specific T cell responses in combination with host genetic 
      markers, such as chemokine/chemokine-receptor (CCR) polymorphisms and human 
      leukocyte antigen (HLA) genotypes. HIV-specific CD4(+) T cell responses and, to a 
      lesser extent, HIV-specific CD8(+) T cell responses were inversely correlated 
      with progression rate. Slower progression was not related to polymorphisms in CCR 
      genes, HLA genotype, or GB virus C coinfection. These data suggest that 
      HIV-specific T cell responses are involved in protecting the host from disease 
      progression.
FAU - Oxenius, Annette
AU  - Oxenius A
AD  - Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Zurich, 
      Switzerland. oxenius@micro.biol.ethz.ch.
FAU - Price, David A
AU  - Price DA
FAU - Hersberger, Martin
AU  - Hersberger M
FAU - Schlaepfer, Erika
AU  - Schlaepfer E
FAU - Weber, Rainer
AU  - Weber R
FAU - Weber, Markus
AU  - Weber M
FAU - Kundig, Thomas M
AU  - Kundig TM
FAU - Boni, Jurg
AU  - Boni J
FAU - Joller, Helen
AU  - Joller H
FAU - Phillips, Rodney E
AU  - Phillips RE
FAU - Flepp, Markus
AU  - Flepp M
FAU - Opravil, Milos
AU  - Opravil M
FAU - Speck, Roberto F
AU  - Speck RF
CN  - Swiss HIV Cohort Study
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040317
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA Antigens)
RN  - 0 (RNA, Viral)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Flaviviridae Infections/immunology
MH  - GB virus C/immunology
MH  - HIV/genetics/*immunology
MH  - HIV Infections/genetics/*immunology
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - RNA, Viral/*blood
MH  - Receptors, Chemokine/genetics/immunology
MH  - Statistics, Nonparametric
MH  - Viral Load
EDAT- 2004/03/20 05:00
MHDA- 2004/05/14 05:00
CRDT- 2004/03/20 05:00
PHST- 2003/03/06 00:00 [received]
PHST- 2003/09/11 00:00 [accepted]
PHST- 2004/03/20 05:00 [pubmed]
PHST- 2004/05/14 05:00 [medline]
PHST- 2004/03/20 05:00 [entrez]
AID - JID30776 [pii]
AID - 10.1086/382028 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Apr 1;189(7):1199-208. doi: 10.1086/382028. Epub 2004 Mar 17.