PMID- 15032573
OWN - NLM
STAT- MEDLINE
DCOM- 20040802
LR  - 20061115
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 22
DP  - 2004
TI  - Self- and nonself-recognition by C-type lectins on dendritic cells.
PG  - 33-54
AB  - Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that 
      collect antigen in body tissues and transport them to draining lymph nodes. 
      Antigenic peptides are loaded onto major histocompatibility complex (MHC) 
      molecules for presentation to naive T cells, resulting in the induction of 
      cellular and humoral immune responses. DCs take up antigen through phagocytosis, 
      pinocytosis, and endocytosis via different groups of receptor families, such as 
      Fc receptors for antigen-antibody complexes, C-type lectin receptors (CLRs) for 
      glycoproteins, and pattern recognition receptors, such as Toll-like receptors 
      (TLRs), for microbial antigens. Uptake of antigen by CLRs leads to presentation 
      of antigens on MHC class I and II molecules. DCs are well equipped to distinguish 
      between self- and nonself-antigens by the variable expression of cell-surface 
      receptors such as CLRs and TLRs. In the steady state, DCs are not immunologically 
      quiescent but use their antigen-handling capacities to maintain peripheral 
      tolerance. DCs are continuously sampling and presenting self- and harmless 
      environmental proteins to silence immune activation. Uptake of self-components in 
      the intestine and airways are good examples of sites where continuous 
      presentation of self- and foreign antigens occurs without immune activation. In 
      contrast, efficient antigen-specific immune activation occurs upon encounter of 
      DCs with nonself-pathogens. Recognition of pathogens by DCs triggers specific 
      receptors such as TLRs that result in DC maturation and subsequently immune 
      activation. Here we discuss the concept that cross talk between TLRs and CLRs, 
      differentially expressed by subsets of DCs, accounts for the different pathways 
      to peripheral tolerance, such as deletion and suppression, and immune activation.
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
AD  - Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical 
      Center Amsterdam, 1081 BT Amsterdam, Netherlands.
FAU - van Vliet, Sandra J
AU  - van Vliet SJ
FAU - Engering, Anneke
AU  - Engering A
FAU - 't Hart, Bert A
AU  - 't Hart BA
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Cell Communication/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lectins, C-Type/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Membrane Glycoproteins/immunology
MH  - Receptors, Cell Surface/immunology
MH  - Self Tolerance/*immunology
MH  - Signal Transduction/*immunology
MH  - Toll-Like Receptors
RF  - 125
EDAT- 2004/03/23 05:00
MHDA- 2004/08/03 05:00
CRDT- 2004/03/23 05:00
PHST- 2004/03/23 05:00 [pubmed]
PHST- 2004/08/03 05:00 [medline]
PHST- 2004/03/23 05:00 [entrez]
AID - 10.1146/annurev.immunol.22.012703.104558 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2004;22:33-54. doi: 10.1146/annurev.immunol.22.012703.104558.