PMID- 15033702
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1010
DP  - 2003 Dec
TI  - Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-alpha.
PG  - 100-3
AB  - We investigated whether repression of JNK by hepatocyte growth factor/scatter 
      factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect 
      cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a 
      well-known inducer of JNK and of cell death, and the effects of HGF/SF were 
      investigated under these conditions. We identified repression of JNK as a 
      signaling target of HGF/SF for protection against TNF-alpha-induced cell death. 
      This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.
FAU - Reveneau, Sylvie
AU  - Reveneau S
AD  - Ecole Pratique des Hautes Etudes, Institut National de la Sante et de la 
      Recherche Medicale U517, BP 87900, 21079 Dijon, France. 
      Sylvie.Reveneau@u-bourgogne.fr
FAU - Paumelle, Rejane
AU  - Paumelle R
FAU - Deheuninck, Julien
AU  - Deheuninck J
FAU - Leroy, Catherine
AU  - Leroy C
FAU - De Launoit, Yvan
AU  - De Launoit Y
FAU - Fafeur, Veronique
AU  - Fafeur V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Chromones)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Morpholines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/*physiology
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Chromones/pharmacology
MH  - Dogs
MH  - Enzyme Inhibitors/pharmacology
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - *JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase 4
MH  - Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
MH  - Morpholines/pharmacology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Urothelium
EDAT- 2004/03/23 05:00
MHDA- 2004/06/16 05:00
CRDT- 2004/03/23 05:00
PHST- 2004/03/23 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2004/03/23 05:00 [entrez]
AID - 10.1196/annals.1299.016 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2003 Dec;1010:100-3. doi: 10.1196/annals.1299.016.