PMID- 15034225
OWN - NLM
STAT- MEDLINE
DCOM- 20040510
LR  - 20081121
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 49
IP  - 3
DP  - 2004
TI  - Monocyte chemoattractant protein-1 promoter -2518 polymorphism may have an 
      influence on clinical heterogeneity of bipolar I disorder in the Korean 
      population.
PG  - 111-4
AB  - The aim of this study was to investigate the association between monocyte 
      chemoattractant protein-1 (MCP1) promoter -2518 polymorphism and DSM-IV-based 
      bipolar I disorder (BID) in Korea. Ninety-two patients with BID and 114 healthy 
      controls participated in this study. A polymerase chain reaction-based method was 
      used for genotyping. Genotype and allele distributions in patients with BID were 
      not different from those of the controls, nor were they different according to 
      clinical factors in the patient group. However, the frequency of the A allele (p 
      = 0.028) was significantly different when subdividing the patient group into 
      patients with manic episode versus depressed and mixed episode. The present study 
      suggests that the MCP1 promoter -2518 polymorphism may not confer susceptibility 
      to BID itself, but could have an influence on the clinical heterogeneity of BID, 
      at least in the Korean population.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Pae, Chi-Un
AU  - Pae CU
AD  - Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, Korea.
FAU - Kim, Jung-Jin
AU  - Kim JJ
FAU - Yu, Hye-Sook
AU  - Yu HS
FAU - Lee, Chang-Uk
AU  - Lee CU
FAU - Lee, Soo-Jung
AU  - Lee SJ
FAU - Jun, Tae-Youn
AU  - Jun TY
FAU - Lee, Chul
AU  - Lee C
FAU - Paik, In-Ho
AU  - Paik IH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Chi-Square Distribution
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Heterogeneity
MH  - Genotype
MH  - Humans
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - *Promoter Regions, Genetic
MH  - RNA, Messenger/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
EDAT- 2004/03/23 05:00
MHDA- 2004/05/11 05:00
CRDT- 2004/03/23 05:00
PHST- 2004/03/23 05:00 [pubmed]
PHST- 2004/05/11 05:00 [medline]
PHST- 2004/03/23 05:00 [entrez]
AID - 76718 [pii]
AID - 10.1159/000076718 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2004;49(3):111-4. doi: 10.1159/000076718.