PMID- 15036206
OWN - NLM
STAT- MEDLINE
DCOM- 20041026
LR  - 20220321
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 15
IP  - 1
DP  - 2004 Feb
TI  - Tau protein and neurodegeneration.
PG  - 45-9
AB  - Tau protein is the major component of the intracellular filamentous deposits that 
      define a number of neurodegenerative diseases. They include the largely sporadic 
      Alzheimer's disease, progressive supranuclear palsy (PSP), corticobasal 
      degeneration (CBD), Pick's disease (PiD), argyrophilic grain disease, as well as 
      the inherited frontotemporal dementia and parkinsonism linked to chromosome 17 
      (FTDP-17). The identification of mutations in Tau as the cause of FTDP-17 
      established that dysfunction or misregulation of tau protein is sufficient to 
      cause neurodegeneration and dementia. At an experimental level, the new 
      understanding is leading to the development of good transgenic animal models of 
      the tauopathies.
FAU - Goedert, Michel
AU  - Goedert M
AD  - Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge 
      CB2 2QH, UK. mg@mrc-lmb.cam.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (Amyloid)
RN  - 0 (Glycosaminoglycans)
RN  - 0 (MAPT protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Alternative Splicing
MH  - Amyloid/chemistry/metabolism/ultrastructure
MH  - Animals
MH  - Brain/metabolism/pathology
MH  - Dementia/etiology/genetics/physiopathology
MH  - Disease Models, Animal
MH  - Glycosaminoglycans/chemistry/metabolism
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Electron
MH  - Microtubules/metabolism
MH  - Mutation/genetics
MH  - Nerve Tissue Proteins/chemistry/*genetics
MH  - Neurodegenerative Diseases/etiology/genetics
MH  - Parkinsonian Disorders/etiology/genetics/physiopathology
MH  - Pick Disease of the Brain/etiology/genetics
MH  - Protein Binding
MH  - Protein Isoforms/chemistry/genetics
MH  - Supranuclear Palsy, Progressive/etiology/genetics
MH  - Tauopathies/etiology/*genetics
MH  - tau Proteins
RF  - 34
EDAT- 2004/03/24 05:00
MHDA- 2004/10/27 09:00
CRDT- 2004/03/24 05:00
PHST- 2004/03/24 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2004/03/24 05:00 [entrez]
AID - S1084-9521(03)00120-4 [pii]
AID - 10.1016/j.semcdb.2003.12.015 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2004 Feb;15(1):45-9. doi: 10.1016/j.semcdb.2003.12.015.