PMID- 15036600
OWN - NLM
STAT- MEDLINE
DCOM- 20040603
LR  - 20181130
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 357
IP  - 1
DP  - 2004 Feb 26
TI  - Tyrosine augments clozapine-induced dopamine release in the medial prefrontal 
      cortex of the rat in vivo: effects of access to food.
PG  - 5-8
AB  - It has been reported that tyrosine administration augments clozapine-induced 
      dopamine (DA) release in the medial prefrontal cortex (MPFC). To characterize 
      this effect and exclude possible confounds, we conducted a series of studies in 
      which microdialysate collection started 24 h after probe implantation, a time at 
      which most collected DA is thought to be impulse mediated. Tyrosine (25 or 50 
      mg/kg IP) administered 30 min after clozapine (10 mg/kg IP) augmented 
      clozapine-induced MPFC but not striatal DA release. While tyrosine potentiation 
      was also evident in both fasted animals and those with free access to food, the 
      effective doses of tyrosine varied. We confirm that tyrosine administration can 
      potentiate clozapine-induced MPFC DA release but note that the effect is not 
      evident across all doses and conditions.
FAU - Jaskiw, George E
AU  - Jaskiw GE
AD  - Psychiatry Service 116A(B), Louis Stokes Cleveland Veterans Affairs Medical 
      Center, 10000 Brecksville Road, Brecksville, OH 44141, USA. 
      george.jaskiw@case.edu
FAU - Simpson, Catherine
AU  - Simpson C
FAU - Bongiovanni, Rodolfo
AU  - Bongiovanni R
FAU - Yamamoto, Bryan K
AU  - Yamamoto BK
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antipsychotic Agents)
RN  - 42HK56048U (Tyrosine)
RN  - J60AR2IKIC (Clozapine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/pharmacology
MH  - Clozapine/*pharmacology
MH  - Dopamine/biosynthesis/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions/physiology
MH  - Drug Synergism
MH  - Eating/drug effects/physiology
MH  - Extracellular Fluid/drug effects/metabolism
MH  - Microdialysis
MH  - Neostriatum/drug effects/metabolism
MH  - Neural Pathways/*drug effects/metabolism
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects/physiology
MH  - Schizophrenia/metabolism/physiopathology
MH  - Tyrosine/*metabolism/pharmacology
EDAT- 2004/03/24 05:00
MHDA- 2004/06/04 05:00
CRDT- 2004/03/24 05:00
PHST- 2003/07/03 00:00 [received]
PHST- 2003/11/05 00:00 [revised]
PHST- 2003/11/08 00:00 [accepted]
PHST- 2004/03/24 05:00 [pubmed]
PHST- 2004/06/04 05:00 [medline]
PHST- 2004/03/24 05:00 [entrez]
AID - S0304394003014241 [pii]
AID - 10.1016/j.neulet.2003.11.060 [doi]
PST - ppublish
SO  - Neurosci Lett. 2004 Feb 26;357(1):5-8. doi: 10.1016/j.neulet.2003.11.060.