PMID- 15036758
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20171116
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 196
IP  - 1-2
DP  - 2004 Mar 1
TI  - Effects of prenatal exposure to the environmental pollutant 2-bromopropane on 
      embryo-fetal development in rats.
PG  - 77-86
AB  - 2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for 
      chlorofluorocarbones. The present study was carried out to investigate the 
      potential adverse effects of 2-BP on pregnant dams and embryo-fetal development 
      after maternal exposure on gestational days (GD) 6 through 19 in Sprague-Dawley 
      rats. The test chemical was administered subcutaneously to pregnant rats at dose 
      levels of 0, 250, 500, and 1000 mg/kg per day. All dams were subjected to 
      caesarean section on GD 20 and their fetuses were examined for external, visceral 
      and skeletal abnormalities. In the 1000 mg/kg group, maternal toxicity included 
      an increase in the incidence of abnormal clinical signs, a suppression in the 
      body weight and body weight gain, and a decrease in the food intake. 
      Developmental toxicity included an increase in the fetal deaths, a decrease in 
      the litter size, and a reduction in the fetal body weight. In addition, an 
      increase in the incidence of fetal external, visceral, and skeletal abnormalities 
      was seen. In the 500 mg/kg group, minimal developmental toxicity including 
      decreased fetal body weight and increased fetal ossification delay was observed. 
      There were no adverse effects on either pregnant dams or embryo-fetal development 
      in the 250 mg/kg group. These findings suggest that a 14-day subcutaneous dose of 
      2-BP is embryotoxic and teratogenic at a maternally toxic dose (i.e., 1000 mg/kg 
      per day) and is minimally embryotoxic at a nonmaternally toxic dose (i.e., 500 
      mg/kg per day) in Sprague-Dawley rats. In the present experimental conditions, 
      the no-observed-adverse-effect level (NOAEL) of 2-BP is considered to be 500 
      mg/kg per day for dams and 250 mg/kg per day for embryo-fetal development.
FAU - Kim, Jong-Choon
AU  - Kim JC
AD  - Department of Toxicology, College of Veterinary Medicine, Chonnam National 
      University, Gwangju 500-757, South Korea. toxkim@chonnam.ac.kr
FAU - Kim, Sung-Ho
AU  - Kim SH
FAU - Shin, Dong-Ho
AU  - Shin DH
FAU - Ahn, Tae-Ho
AU  - Ahn TH
FAU - Kim, Hyoung-Chin
AU  - Kim HC
FAU - Kim, Yun-Bae
AU  - Kim YB
FAU - Jiang, Cheng-Zhe
AU  - Jiang CZ
FAU - Han, Junghee
AU  - Han J
FAU - Chung, Moon-Koo
AU  - Chung MK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Mutagens)
RN  - R651XOV97Z (2-bromopropane)
SB  - IM
MH  - Abnormalities, Drug-Induced/pathology
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cesarean Section
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Embryonic and Fetal Development/*drug effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Growth/drug effects
MH  - Hydrocarbons, Brominated/*toxicity
MH  - Male
MH  - Mutagens/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/drug effects
MH  - Skin Absorption
EDAT- 2004/03/24 05:00
MHDA- 2004/04/07 05:00
CRDT- 2004/03/24 05:00
PHST- 2003/08/06 00:00 [received]
PHST- 2003/11/12 00:00 [revised]
PHST- 2003/11/12 00:00 [accepted]
PHST- 2004/03/24 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2004/03/24 05:00 [entrez]
AID - S0300483X03005055 [pii]
AID - 10.1016/j.tox.2003.11.006 [doi]
PST - ppublish
SO  - Toxicology. 2004 Mar 1;196(1-2):77-86. doi: 10.1016/j.tox.2003.11.006.