PMID- 15040649
OWN - NLM
STAT- MEDLINE
DCOM- 20040819
LR  - 20190917
IS  - 0277-0008 (Print)
IS  - 0277-0008 (Linking)
VI  - 24
IP  - 3
DP  - 2004 Mar
TI  - Assessment of hypothyroidism in patients with chronic heart failure.
PG  - 358-61
AB  - STUDY OBJECTIVE: To determine whether appropriate thyroid function measurements 
      were being conducted in patients receiving care at a multidisciplinary heart 
      failure clinic. DESIGN: Retrospective chart review. SETTING: 
      University-affiliated outpatient clinic. PATIENTS: One hundred ninety-three 
      patients with heart failure. INTERVENTION: Patients enrolled in the heart failure 
      clinic at the Medical University of South Carolina from January 2000-April 2003 
      were identified. Their medical records were reviewed for demographics, New York 
      Heart Association (NYHA) functional classification, laboratory data, and date of 
      most recent heart failure clinic appointment. MEASUREMENTS AND MAIN RESULTS: The 
      records of 193 patients (43% women) were reviewed. Overall and subgroup analyses 
      were performed based on patient characteristics such as presence of 
      thyroid-stimulating hormone (TSH) level, interval since last heart failure clinic 
      appointment, presence of thyroid replacement therapy, amiodarone use, NYHA 
      functional class, and attending physician. Of the 193 patients, 77 (40%) had 
      appropriate TSH monitoring, whereas 10 (32%) of 31 patients receiving amiodarone 
      had appropriate monitoring. Forty-four (27%) patients not receiving amiodarone 
      had no record of a TSH level. In 22 patients (11%), hypothyroidism was diagnosed 
      and treated, whereas 16 patients (8%) had an abnormal TSH level but received no 
      therapy. CONCLUSION: Forty percent of the 193 patients at this outpatient heart 
      failure clinic received appropriate TSH monitoring. An opportunity exists for 
      protocol implementation and education of pharmacists, nurse practitioners, and 
      physicians concerning appropriate thyroid function monitoring in the heart 
      failure population.
FAU - Middleton, Sarah C
AU  - Middleton SC
AD  - Department of Pharmacy Services, Greenville Hospital System, Greenville, South 
      Carolina, USA.
FAU - Spencer, Anne P
AU  - Spencer AP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
RN  - 9002-71-5 (Thyrotropin)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - Aged
MH  - Amiodarone/therapeutic use
MH  - Diagnostic Errors
MH  - Female
MH  - Heart Failure/*complications/diagnosis/drug therapy
MH  - Humans
MH  - Hypothyroidism/*complications/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - South Carolina
MH  - Thyroid Function Tests/statistics & numerical data
MH  - Thyrotropin/blood
MH  - Treatment Failure
EDAT- 2004/03/26 05:00
MHDA- 2004/08/20 05:00
CRDT- 2004/03/26 05:00
PHST- 2004/03/26 05:00 [pubmed]
PHST- 2004/08/20 05:00 [medline]
PHST- 2004/03/26 05:00 [entrez]
AID - 10.1592/phco.24.4.358.33171 [doi]
PST - ppublish
SO  - Pharmacotherapy. 2004 Mar;24(3):358-61. doi: 10.1592/phco.24.4.358.33171.