PMID- 15040690
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20111117
IS  - 0022-3395 (Print)
IS  - 0022-3395 (Linking)
VI  - 90
IP  - 1
DP  - 2004 Feb
TI  - Variation of circumsporozoite 26 and 29 genotypes of Plasmodium falciparum 
      infecting patients and association with HLA-DQA allotypes in western Thailand.
PG  - 182-4
AB  - We evaluated the proportion of variants of circumsporozoite protein (cp) gene 26 
      and cp29 antigenic epitopes of Plasmodium falciparum infecting patients among 3 
      provinces in western Thailand, in addition to published variants from Gambia. The 
      proportion of patients coinfected with cp26 and cp29 strains was significantly 
      higher in patients reporting to malaria clinics in Tak than in Kanchanaburi and 
      Ratchaburi and higher in Kanchanaburi than in Ratchaburi. In western Thailand, 
      coinfection with cp26 and cp29 appears to increase with increasing latitude. 
      There were also significant differences in proportion of these variants among 
      Thai provinces and Gambia. An association of patient human leukocyte antigen 
      (HLA) class II genotype was associated with P. falciparum strains. There were 
      significant associations among the HLA-DQA alleles in patients, the province of 
      origin, and cp variants of P. falciparum.
FAU - Kollars, Thomas M Jr
AU  - Kollars TM Jr
AD  - Entomological Sciences Program, U.S. Army Center for Health Promotion and 
      Preventive Medicine, Aberdeen Proving Ground, Maryland 21010, USA. 
      thomas.kollars@apg.amedd.army.mil
FAU - Phasuk, Rungnapha
AU  - Phasuk R
FAU - Sattabongkot, Jetsumon
AU  - Sattabongkot J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Parasitol
JT  - The Journal of parasitology
JID - 7803124
RN  - 0 (Epitopes)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (Protozoan Proteins)
RN  - 0 (circumsporozoite protein, Protozoan)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Epitopes/genetics/immunology
MH  - Female
MH  - *Genetic Variation
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DQ alpha-Chains
MH  - Humans
MH  - Linear Models
MH  - Malaria, Falciparum/epidemiology/immunology/*parasitology
MH  - Male
MH  - Middle Aged
MH  - Plasmodium falciparum/classification/*genetics/immunology
MH  - Polymerase Chain Reaction
MH  - Protozoan Proteins/*genetics/immunology
MH  - Thailand/epidemiology
EDAT- 2004/03/26 05:00
MHDA- 2004/04/07 05:00
CRDT- 2004/03/26 05:00
PHST- 2004/03/26 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2004/03/26 05:00 [entrez]
AID - 10.1645/GE-13R [doi]
PST - ppublish
SO  - J Parasitol. 2004 Feb;90(1):182-4. doi: 10.1645/GE-13R.