PMID- 15040938
OWN - NLM
STAT- MEDLINE
DCOM- 20040427
LR  - 20061115
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 22
IP  - 7
DP  - 2004 Feb 17
TI  - Dendritic cell-based vaccination against opportunistic fungi.
PG  - 857-64
AB  - Efficient responses to the different forms of fungi require different mechanisms 
      of immunity. Dendritic cells (DCs) are uniquely able to decode the 
      fungus-associated information and translate it in qualitatively different T 
      helper (Th) immune responses, in vitro and in vivo. DCs sense fungi in a 
      morphotype-specific manner, through the engagement of distinct recognition 
      receptors ultimately affecting cytokine production and costimulation. Adoptive 
      transfer of different types of DCs activates protective and non-protective Th 
      cells as well as regulatory T cells and affects the outcome of the infections. 
      DCs transfected with fungal RNA also restore antifungal resistance in 
      hematopoietic transplantation. Thus, the remarkable functional plasticity of DCs 
      in response to fungi can be exploited for the deliberate targeting of cells and 
      pathways of cell-mediated immunity in response to fungal vaccines.
FAU - Bozza, Silvia
AU  - Bozza S
AD  - Department of Experimental Medicine and Biochemical Sciences, Medical School, 
      University of Perugia, 06122 Perugia, Italy.
FAU - Montagnoli, Claudia
AU  - Montagnoli C
FAU - Gaziano, Roberta
AU  - Gaziano R
FAU - Rossi, Giordano
AU  - Rossi G
FAU - Nkwanyuo, Gabriel
AU  - Nkwanyuo G
FAU - Bellocchio, Silvia
AU  - Bellocchio S
FAU - Romani, Luigina
AU  - Romani L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Fungal Vaccines)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Fungal Vaccines/*immunology
MH  - Fungi/immunology
MH  - Humans
MH  - Mycoses/*prevention & control
MH  - Opportunistic Infections/*prevention & control
MH  - T-Lymphocytes, Helper-Inducer/immunology
MH  - *Vaccination
RF  - 48
EDAT- 2004/03/26 05:00
MHDA- 2004/04/28 05:00
CRDT- 2004/03/26 05:00
PHST- 2004/03/26 05:00 [pubmed]
PHST- 2004/04/28 05:00 [medline]
PHST- 2004/03/26 05:00 [entrez]
AID - S0264410X03008284 [pii]
AID - 10.1016/j.vaccine.2003.11.031 [doi]
PST - ppublish
SO  - Vaccine. 2004 Feb 17;22(7):857-64. doi: 10.1016/j.vaccine.2003.11.031.