PMID- 15042832
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20080823
IS  - 0026-8984 (Print)
IS  - 0026-8984 (Linking)
VI  - 38
IP  - 1
DP  - 2004 Jan-Feb
TI  - [Fluorescence in situ hybridization in studying the human genome].
PG  - 17-28
AB  - Physical chromosome mapping by fluorescence in situ hybridization (FISH) is among 
      the major lines of research on the human genome (as well as genomes of numerous 
      other organisms). To localize particular genes or anonymous DNA sequences on 
      individual chromosomes or chromosome regions, FISH was developed in the late 
      1980s and early 1990s, when the International Human Genome Project and the 
      Russian program Human Genome were launched. Now FISH continues to play a 
      prominent part in studies of the human genome. The review considers the major 
      steps of FISH development in Russia with special emphasis on the key roles of the 
      Institute of Cytology and Genetics (Novosibirsk) and Engelhardt Institute of 
      Molecular Biology (Moscow). Physical mapping of human chromosomes 3 and 13 by 
      FISH is described in detail. The promotion of FISH in Russia contributed to the 
      progress in the related fields such as comparative animal genomics (ZOO-FISH) and 
      studies of plant chromosomes.
FAU - Zelenin, A V
AU  - Zelenin AV
AD  - Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 
      119991 Russia. azel@eimb.ru
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Fluorestsentnaia gibridizatsiia in situ v izuchenii genoma cheloveka.
PL  - Russia (Federation)
TA  - Mol Biol (Mosk)
JT  - Molekuliarnaia biologiia
JID - 0105454
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
RN  - EC 3.1.21.4 (GCGGCCGC-specific type II deoxyribonucleases)
SB  - IM
MH  - Chromosomes, Human, Pair 13
MH  - Deoxyribonucleases, Type II Site-Specific/metabolism
MH  - *Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics
MH  - Physical Chromosome Mapping
RF  - 99
EDAT- 2004/03/27 05:00
MHDA- 2004/07/14 05:00
CRDT- 2004/03/27 05:00
PHST- 2004/03/27 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2004/03/27 05:00 [entrez]
PST - ppublish
SO  - Mol Biol (Mosk). 2004 Jan-Feb;38(1):17-28.