PMID- 15044257
OWN - NLM
STAT- MEDLINE
DCOM- 20040817
LR  - 20220331
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 104
IP  - 2
DP  - 2004 Jul 15
TI  - Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
PG  - 558-60
AB  - Activating FLT3 mutations are the most common genetic aberrations in acute 
      myeloid leukemia (AML), resulting in the constitutive activation of this receptor 
      tyrosine kinase (RTK), but such mutations are rarely found in acute lymphoblastic 
      leukemia (ALL). Here we describe a unique subset of de novo adult T-cell ALL 
      (T-ALL) cases that coexpress CD117/KIT and cytoplasmic CD3 (CD117/KIT(+) ALL). 
      Activating mutations in the FLT3 RTK gene were found in each of 3 CD117/KIT(+) 
      cases that were analyzed, but not in 52 other adult T-ALL samples from the same 
      series that lacked CD117/KIT expression. Our results indicate the need for 
      clinical trials to test the efficacy of drugs that inhibit the FLT3 RTK in this 
      subset of patients with T-ALL.
FAU - Paietta, Elisabeth
AU  - Paietta E
AD  - Our Lady of Mercy Cancer Center-Immunology Laboratory, 600 East 233rd St, Bronx, 
      NY 10466, USA. epaietta@earthlink.net
FAU - Ferrando, Adolfo A
AU  - Ferrando AA
FAU - Neuberg, Donna
AU  - Neuberg D
FAU - Bennett, John M
AU  - Bennett JM
FAU - Racevskis, Janis
AU  - Racevskis J
FAU - Lazarus, Hillard
AU  - Lazarus H
FAU - Dewald, Gordon
AU  - Dewald G
FAU - Rowe, Jacob M
AU  - Rowe JM
FAU - Wiernik, Peter H
AU  - Wiernik PH
FAU - Tallman, Martin S
AU  - Tallman MS
FAU - Look, A Thomas
AU  - Look AT
LA  - eng
GR  - CA11083/CA/NCI NIH HHS/United States
GR  - CA21115/CA/NCI NIH HHS/United States
GR  - CA23318/CA/NCI NIH HHS/United States
GR  - CA56771/CA/NCI NIH HHS/United States
GR  - CA68484/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040325
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (FLT3 protein, human)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (fms-Like Tyrosine Kinase 3)
SB  - IM
CIN - Blood. 2005 Dec 15;106(13):4414-5. PMID: 16326981
MH  - Amino Acid Sequence
MH  - Gene Expression Regulation, Enzymologic
MH  - Gene Expression Regulation, Leukemic
MH  - Humans
MH  - Molecular Sequence Data
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics/*physiopathology
MH  - Proto-Oncogene Proteins/*genetics/*metabolism
MH  - Proto-Oncogene Proteins c-kit/*genetics/*metabolism
MH  - Receptor Protein-Tyrosine Kinases/*genetics/*metabolism
MH  - fms-Like Tyrosine Kinase 3
EDAT- 2004/03/27 05:00
MHDA- 2004/08/18 05:00
CRDT- 2004/03/27 05:00
PHST- 2004/03/27 05:00 [pubmed]
PHST- 2004/08/18 05:00 [medline]
PHST- 2004/03/27 05:00 [entrez]
AID - S0006-4971(20)55154-9 [pii]
AID - 10.1182/blood-2004-01-0168 [doi]
PST - ppublish
SO  - Blood. 2004 Jul 15;104(2):558-60. doi: 10.1182/blood-2004-01-0168. Epub 2004 Mar 
      25.