PMID- 15046400
OWN - NLM
STAT- MEDLINE
DCOM- 20040930
LR  - 20220408
IS  - 0239-8508 (Print)
IS  - 0239-8508 (Linking)
VI  - 42
IP  - 1
DP  - 2004
TI  - Dendritic cells in peripheral blood of patients with breast and lung cancer--a 
      pilot study.
PG  - 45-8
AB  - Dendritic cells (DCs) are regarded as the most potent antigen presenting cells 
      that are well suited to activate T cells toward various antigens, such as 
      tumor-associated antigens, due to their costimulatory activity. There is evidence 
      that DCs are of diverse origin, with at least two types of myeloid and lymphoid 
      precursors implicated in their generation. The recent reports demonstrated that 
      the number and function of dendritic cells might change dramatically in cancer 
      patients. In the present study we evaluated the percentage of myeloid and 
      lymphoid DCs in patients with breast cancer, non-small cell lung cancer (NSCLC) 
      and in the healthy donors. The percentage of both DC populations was 
      significantly lower in patients with NSCLC than in the control group. In patients 
      with breast cancer, the number of lymphoid DCs was significantly higher than in 
      NSCLC patients. The obtained results suggest influence of pathological states on 
      host immune system. The decrease in the number of DCs in the peripheral blood 
      from cancer patients may be closely correlated with the type of tumour.
FAU - Wojas, Kamila
AU  - Wojas K
AD  - Department of Clinical Immunology, University School of Medicine, Lublin, Poland. 
      kamilawojas@poczta.onet.pl
FAU - Tabarkiewicz, Jacek
AU  - Tabarkiewicz J
FAU - Jankiewicz, Malgorzata
AU  - Jankiewicz M
FAU - Rolinski, Jacek
AU  - Rolinski J
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Histochem Cytobiol
JT  - Folia histochemica et cytobiologica
JID - 8502651
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal
MH  - Breast Neoplasms/*blood/immunology
MH  - Carcinoma, Non-Small-Cell Lung/*blood/immunology
MH  - Cell Count
MH  - Dendritic Cells/immunology/*physiology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Lung Neoplasms/*blood/immunology
MH  - Male
MH  - Monocytes/physiology
MH  - Phenotype
MH  - Pilot Projects
EDAT- 2004/03/30 05:00
MHDA- 2004/10/01 05:00
CRDT- 2004/03/30 05:00
PHST- 2004/03/30 05:00 [pubmed]
PHST- 2004/10/01 05:00 [medline]
PHST- 2004/03/30 05:00 [entrez]
PST - ppublish
SO  - Folia Histochem Cytobiol. 2004;42(1):45-8.