PMID- 1504762
OWN - NLM
STAT- MEDLINE
DCOM- 19920918
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 573
IP  - 2
DP  - 1992 Feb 28
TI  - EEG-dependent modulation of response dynamics of cat dLGN relay cells and the 
      contribution of corticogeniculate feedback.
PG  - 217-27
AB  - Single unit recordings were made extracellularly from the dorsal lateral 
      geniculate nucleus (dLGN) in the anaesthetized and paralysed cat. The impulse 
      rates of phasic (peak) and tonic components of visual responses to stimulation of 
      the receptive field center by a flashing spot were determined during different 
      states of the EEG, during local cortical cooling and during micro-iontophoretic 
      application of the excitatory amino acid receptor agonists, quisqualate (QUIS) 
      and N-methyl-D-aspartate (NMDA). Typically, visual responses were phasic during 
      low frequency/high amplitude EEG patterns, resembling slow wave sleep (SWS). 
      During high frequency EEG patterns (non-SWS) visual responses of X- and Y-cells 
      exhibited a prominent tonic response component. This tonic component could be 
      clearly reduced during ipsilateral cortical cooling in the non-SWS state. QUIS or 
      NMDA, applied in order to mimic corticofugal activity, augmented the tonic 
      response component, most efficiently during SWS EEG. The effects did not differ 
      significantly for X- and Y-cells. During non-SWS EEG Y-cells exhibited a tonic 
      response component similar to X-cells, but because of their higher peak rates the 
      responses of Y-cells were on average more phasic than those of X-cells. Our 
      results indicate that state-dependent changes in CNS activity modulate dL'GN 
      responsiveness in part via the corticogeniculate feedback, and that predominantly 
      the tonic response component is modulated.
FAU - Funke, K
AU  - Funke K
AD  - Abteilung fur Neurophysiologie, Ruhr-Universitat Bochum, F.R.G.
FAU - Eysel, U T
AU  - Eysel UT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
SB  - IM
MH  - Animals
MH  - Cats
MH  - *Electroencephalography/drug effects
MH  - Feedback
MH  - Functional Laterality
MH  - Geniculate Bodies/drug effects/*physiology
MH  - N-Methylaspartate/pharmacology
MH  - Photic Stimulation
MH  - Quisqualic Acid/pharmacology
MH  - Temperature
MH  - Visual Cortex/drug effects/*physiology
EDAT- 1992/02/28 00:00
MHDA- 1992/02/28 00:01
CRDT- 1992/02/28 00:00
PHST- 1992/02/28 00:00 [pubmed]
PHST- 1992/02/28 00:01 [medline]
PHST- 1992/02/28 00:00 [entrez]
AID - 0006-8993(92)90766-3 [pii]
AID - 10.1016/0006-8993(92)90766-3 [doi]
PST - ppublish
SO  - Brain Res. 1992 Feb 28;573(2):217-27. doi: 10.1016/0006-8993(92)90766-3.