PMID- 1504804
OWN - NLM
STAT- MEDLINE
DCOM- 19920923
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 580
IP  - 1-2
DP  - 1992 May 15
TI  - The functional anatomy of manual motor behavior after unilateral frontal lobe 
      lesions.
PG  - 249-54
AB  - In normal brains different behavioral tasks lead to increased metabolism in 
      different loci. Resting monkeys with acute hemineglect following periarcuate 
      lesions show deficient glucose utilization (LCGU) in motor thalamus and other 
      loci of the hemisphere with the lesion. To determine if the abnormal LCGU could 
      be altered by a specific behavioral task, we used behavioral testing and 
      training, and quantitative 2-deoxyglucose (2-DG) autoradiography. Animals reached 
      criterion in a bimanual traction task (BMTT), then were tested for hand 
      preference and responses to sensory stimuli, and received unilateral frontal or 
      sham lesions. Operated animals showed hemineglect, and, on BMTT, intermanual 
      coordination errors. 2-DG of frontals at rest showed deficient LCGU in 4 of 7 
      thalamic, and 1 of 4 cortical regions assessed. In contrast, only 2 thalamic and 
      no cortical regions were deficient in pulling animals. Thus, in the face of 
      structural damage and distant deficient neural activation, performance of a 
      specific behavioral task may increase metabolism in specific brain loci, implying 
      that plasticity of neural activation vis-a-vis behavioral demand is present even 
      acutely after brain injury.
FAU - Deuel, R K
AU  - Deuel RK
AD  - Department of Pediatrics and Neurology, Washington University School of Medicine, 
      St. Louis, MO 63110.
LA  - eng
GR  - R01 NS16790-08/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Deoxyglucose
MH  - Frontal Lobe/anatomy & histology/*physiology
MH  - Glucose/*metabolism
MH  - Hand/*innervation
MH  - Macaca fascicularis
MH  - Male
MH  - Motor Activity/*physiology
MH  - Thalamus/*physiology
EDAT- 1992/05/15 00:00
MHDA- 1992/05/15 00:01
CRDT- 1992/05/15 00:00
PHST- 1992/05/15 00:00 [pubmed]
PHST- 1992/05/15 00:01 [medline]
PHST- 1992/05/15 00:00 [entrez]
AID - 0006-8993(92)90951-5 [pii]
AID - 10.1016/0006-8993(92)90951-5 [doi]
PST - ppublish
SO  - Brain Res. 1992 May 15;580(1-2):249-54. doi: 10.1016/0006-8993(92)90951-5.