PMID- 15049796
OWN - NLM
STAT- MEDLINE
DCOM- 20040706
LR  - 20131121
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 8
IP  - 2
DP  - 2004 Apr
TI  - Hyperhomocysteinemia in pediatric and young adult renal transplant recipients.
PG  - 161-6
AB  - Hyperhomocysteinemia (HHcy) has been recently identified as an important and 
      reversible cardiovascular risk factor in adult and pediatric renal transplant 
      recipients. A retrospective cross-sectional analysis of 70 pediatric and young 
      adult renal transplant recipients was performed to determine the prevalence, and 
      important clinical and laboratory correlates of HHcy. Total homocysteine 
      concentration, free and protein bound, was determined by fluorescence 
      polarization immunoassay using an IMX analyzer. Hyperhomocysteinemia was defined 
      as a serum homocysteine (Hcy) level above the 95th percentile for age. Fifty-four 
      of 70 patients (77%) had HHcy. Comparison of patients with HHcy with patients 
      without HHcy demonstrated no statistical difference in age (p = 0.35), gender (p 
      = 0.76) or donor type (p = 0.20). Patients with HHcy had significantly lower 
      calculated creatinine clearance values (Ccr) (p = 0.02), 67.3 +/- 21.2 
      mL/min/1.73 m(2) vs. 90.7 +/- 32.3 mL/min/1.73 m(2) for patients without HHcy. 
      Immunosuppression did not correlate with the diagnosis of HHcy. Stepwise logistic 
      regression identified patient age (0.18, p = 0.013) and Ccr (-0.04, p = 0.011) as 
      significant variables. In conclusion, HHcy is more common than expected in 
      pediatric renal transplant recipients. Patients with Ccr <80 mL/min/1.73 m(2) 
      were statistically more likely to have a diagnosis of HHcy. We recommend that Hcy 
      levels should be evaluated in this high risk population.
FAU - Belson, Amir
AU  - Belson A
AD  - Section of Pediatric Nephrology, Department of Pediatrics, Lucile Salter Packard 
      Children's Hospital, Stanford University, CA 94304, USA. abelson@stanford.edu
FAU - Sanchez, Jaime
AU  - Sanchez J
FAU - Alexander, Steven R
AU  - Alexander SR
FAU - Salvatierra, Oscar
AU  - Salvatierra O
FAU - Dar, Mor H
AU  - Dar MH
FAU - Reif, Shimon
AU  - Reif S
FAU - Yorgin, Peter D
AU  - Yorgin PD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
RN  - 0 (Immunosuppressive Agents)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Creatinine/metabolism
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescence Polarization Immunoassay/instrumentation
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*etiology
MH  - Immunosuppressive Agents/classification/therapeutic use
MH  - *Kidney Transplantation/adverse effects
MH  - Logistic Models
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Tissue Donors
EDAT- 2004/03/31 05:00
MHDA- 2004/07/09 05:00
CRDT- 2004/03/31 05:00
PHST- 2004/03/31 05:00 [pubmed]
PHST- 2004/07/09 05:00 [medline]
PHST- 2004/03/31 05:00 [entrez]
AID - PTR144 [pii]
AID - 10.1046/j.1399-3046.2003.00144.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2004 Apr;8(2):161-6. doi: 10.1046/j.1399-3046.2003.00144.x.