PMID- 15050452
OWN - NLM
STAT- MEDLINE
DCOM- 20040604
LR  - 20081121
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 219
IP  - 1-2
DP  - 2004 Apr 15
TI  - Serum concentration and genetic polymorphism in the 5'-untraslated region of VEGF 
      is not associated with susceptibility to HTLV-I associated myelopathy/tropical 
      spastic paraparesis (HAM/TSP) in HTLV-I infected individuals.
PG  - 157-61
AB  - HTLV-I- associated myelopathy/tropical spastic paraparesis (HAM/TSP) is one 
      outcome of human T-cell lymphotropic virus type I (HTLV-I) infection. It remains 
      unknown why the majority of infected people remain healthy whereas only 
      approximately 2-3% of infected individuals develop the disease. Recently, it has 
      been reported that increased plasma concentrations of VEGF were significantly 
      related to high ATL cell infiltration, and the viral transactivator Tax activates 
      the VEGF promoter, linking the induction of angiogenesis to viral gene 
      expression. To investigate whether VEGF promoter -634C/G single nucleotide 
      polymorphism (SNP) and serum concentration of VEGF are associated with the 
      development of HAM/TSP, we studied a group of 202 HAM/TSP patients, 202 
      asymptomatic HTLV-I seropositive carriers (HCs) and 108 seronegative healthy 
      controls (NCs) in Kagoshima, Japan by using PCR-RFLP analysis. The serum 
      concentration of VEGF was also compared among patients with HAM/TSP, ATL, HCs as 
      well as with NCs. Our results indicate that both VEGF gene polymorphism and serum 
      VEGF levels are not specifically associated with the risk of HAM/TSP in our 
      cohort.
FAU - Saito, Mineki
AU  - Saito M
AD  - Department of Neurology and Geriatrics, Kagoshima University Graduate School of 
      Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. 
      mineki@m3.kufm.kagoshima-u.ac.jp
FAU - Usuku, Koichiro
AU  - Usuku K
FAU - Nobuhara, Yasuyuki
AU  - Nobuhara Y
FAU - Matsumoto, Wataru
AU  - Matsumoto W
FAU - Kodama, Daisuke
AU  - Kodama D
FAU - Sabouri, Amir H
AU  - Sabouri AH
FAU - Izumo, Shuji
AU  - Izumo S
FAU - Arimura, Kimiyoshi
AU  - Arimura K
FAU - Osame, Mitsuhiro
AU  - Osame M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - 5' Untranslated Regions/genetics
MH  - Antibodies, Viral/blood
MH  - Carrier State
MH  - Genetic Predisposition to Disease
MH  - Human T-lymphotropic virus 1/immunology/*isolation & purification
MH  - Humans
MH  - Paraparesis, Tropical Spastic/*blood/*genetics/virology
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Proviruses
MH  - Vascular Endothelial Growth Factor A/*blood/*genetics
MH  - Viral Load
EDAT- 2004/03/31 05:00
MHDA- 2004/06/05 05:00
CRDT- 2004/03/31 05:00
PHST- 2003/09/09 00:00 [received]
PHST- 2003/12/03 00:00 [revised]
PHST- 2004/01/21 00:00 [accepted]
PHST- 2004/03/31 05:00 [pubmed]
PHST- 2004/06/05 05:00 [medline]
PHST- 2004/03/31 05:00 [entrez]
AID - S0022510X04000255 [pii]
AID - 10.1016/j.jns.2004.01.009 [doi]
PST - ppublish
SO  - J Neurol Sci. 2004 Apr 15;219(1-2):157-61. doi: 10.1016/j.jns.2004.01.009.