PMID- 15050489
OWN - NLM
STAT- MEDLINE
DCOM- 20040427
LR  - 20061115
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 93
IP  - 7
DP  - 2004 Apr 1
TI  - Comparison of benefits from cardiac resynchronization therapy in patients with 
      ischemic cardiomyopathy versus idiopathic dilated cardiomyopathy.
PG  - 860-3
AB  - Cardiac resynchronization therapy (CRT) is a recently introduced therapeutic 
      option for patients with severe heart failure and intraventricular conduction 
      disturbances. However, it is estimated that 20% to 30% of patients may not 
      respond to CRT. Patients with ischemic cardiomyopathy (IC) may respond less 
      favorably to CRT compared with patients with idiopathic dilated cardiomyopathy 
      (IDC). Accordingly, the beneficial effects of CRT were evaluated in 2 subsets of 
      patients (IC and IDC). Seventy-four patients with end-stage heart failure, New 
      York Heart Association (NYHA) class III or IV, left ventricular (LV) ejection 
      fraction <35%, QRS >120ms, and left bundle branch block received a biventricular 
      pacemaker. At baseline and 6 months after implantation these parameters were 
      evaluated: NYHA class, Minnesota quality-of-life score, QRS duration, and 
      6-minute walking distance. LV ejection fraction and severity of mitral 
      regurgitation were assessed before and 6 months after CRT using 2-dimensional 
      echocardiography. Long-term follow-up and hospitalization rates were obtained up 
      to 2 years. Of the 74 patients, 46% (n = 34) had IC and 54% (n = 40) IDC. At 6 
      months follow-up all clinical parameters, QRS duration, LV ejection fraction, and 
      mitral regurgitation improved significantly in both groups. Long-term (2-year) 
      follow-up showed a survival rate of 87.5% for patients with IDC and 88.3% for 
      patients with IC. The percentages of responders to CRT (defined as an improvement 
      in NYHA class >or=1 grade) were comparable in both groups (65% vs 71%). 
      Therefore, the underlying etiology of heart failure (IC vs IDC) was not related 
      to the response to CRT.
FAU - Molhoek, Sander G
AU  - Molhoek SG
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Bax, Jeroen J
AU  - Bax JJ
FAU - van Erven, Lieselot
AU  - van Erven L
FAU - Bootsma, Marianne
AU  - Bootsma M
FAU - Boersma, Eric
AU  - Boersma E
FAU - Steendijk, Paul
AU  - Steendijk P
FAU - van der Wall, Ernst E
AU  - van der Wall EE
FAU - Schalij, Martin J
AU  - Schalij MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Cardiac Output/*physiology
MH  - *Cardiac Pacing, Artificial
MH  - Cardiomyopathy, Dilated/*mortality/physiopathology/*therapy
MH  - Exercise Tolerance/physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*mortality/physiopathology/*therapy
MH  - Patient Selection
MH  - Quality of Life
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2004/03/31 05:00
MHDA- 2004/04/28 05:00
CRDT- 2004/03/31 05:00
PHST- 2003/09/30 00:00 [received]
PHST- 2003/12/15 00:00 [revised]
PHST- 2003/12/15 00:00 [accepted]
PHST- 2004/03/31 05:00 [pubmed]
PHST- 2004/04/28 05:00 [medline]
PHST- 2004/03/31 05:00 [entrez]
AID - S0002914903017521 [pii]
AID - 10.1016/j.amjcard.2003.12.024 [doi]
PST - ppublish
SO  - Am J Cardiol. 2004 Apr 1;93(7):860-3. doi: 10.1016/j.amjcard.2003.12.024.