PMID- 15050751
OWN - NLM
STAT- MEDLINE
DCOM- 20040517
LR  - 20191210
IS  - 0301-472X (Print)
IS  - 0301-472X (Linking)
VI  - 32
IP  - 4
DP  - 2004 Apr
TI  - Factors associated with outcomes of unrelated cord blood transplant: guidelines 
      for donor choice.
PG  - 397-407
AB  - OBJECTIVE: Optimizing cord blood donor selection based mainly on cell dose and 
      human leukocyte antigen (HLA) disparities may further improve results of 
      unrelated cord blood transplants (UCBT). MATERIALS AND RESULTS: We analyzed 550 
      UCBTs for hematologic malignancies reported to the Eurocord Registry. Main 
      outcomes and prognostic factors were analyzed in univariable and multivariable 
      analyses incorporating center and period effects and using death and relapse as 
      competitive risks for nonfatal endpoints. Nucleated cell (NC) dose before 
      freezing and number of HLA disparities had a significant influence on outcome. 
      Cumulative incidence (CI) of neutrophil and platelet recovery was associated with 
      the number of HLA mismatches, number of NC before freezing, and use of 
      granulocyte colony-stimulating factor. Coexistence of HLA class I and II 
      disparities and high CD34 cell dose in the graft were associated with 
      graft-vs-host disease grades III-IV. CI of disease relapse was higher in matched 
      transplants showing a graft-vs-leukemia effect increased in HLA-mismatched 
      transplants. Overall 3-year survival was 34.4%. Prognostic factors for survival 
      were recipient age, gender, and disease status. CONCLUSION: Our results provide 
      indications for a better choice of cord blood units according to cord blood cell 
      content and HLA.
FAU - Gluckman, Eliane
AU  - Gluckman E
AD  - Bone Marrow Transplant Unit and Eurocord Registry, Laboratory of Clinical 
      Research on Cell Therapy, Saint Louis Hospital AP-HP University Paris VII, Paris, 
      France. elaine.gluckman@sls.ap-hop-paris.fr
FAU - Rocha, Vanderson
AU  - Rocha V
FAU - Arcese, William
AU  - Arcese W
FAU - Michel, Gerard
AU  - Michel G
FAU - Sanz, Guillermo
AU  - Sanz G
FAU - Chan, Ka-Wah
AU  - Chan KW
FAU - Takahashi, Tsuneo A
AU  - Takahashi TA
FAU - Ortega, Juan
AU  - Ortega J
FAU - Filipovich, Alexandra
AU  - Filipovich A
FAU - Locatelli, Franco
AU  - Locatelli F
FAU - Asano, Shigetaka
AU  - Asano S
FAU - Fagioli, Franca
AU  - Fagioli F
FAU - Vowels, Marcus
AU  - Vowels M
FAU - Sirvent, Anne
AU  - Sirvent A
FAU - Laporte, Jean-Philippe
AU  - Laporte JP
FAU - Tiedemann, Karin
AU  - Tiedemann K
FAU - Amadori, Sergio
AU  - Amadori S
FAU - Abecassis, Manuel
AU  - Abecassis M
FAU - Bordigoni, Pierre
AU  - Bordigoni P
FAU - Diez, Blanca
AU  - Diez B
FAU - Shaw, Peter J
AU  - Shaw PJ
FAU - Vora, Ajay
AU  - Vora A
FAU - Caniglia, Maurizio
AU  - Caniglia M
FAU - Garnier, Federico
AU  - Garnier F
FAU - Ionescu, Irina
AU  - Ionescu I
FAU - Garcia, Joan
AU  - Garcia J
FAU - Koegler, Gesine
AU  - Koegler G
FAU - Rebulla, Paolo
AU  - Rebulla P
FAU - Chevret, Sylvie
AU  - Chevret S
CN  - Eurocord Group
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (Antigens, CD34)
RN  - 0 (HLA Antigens)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigens, CD34/analysis
MH  - *Blood Cell Count
MH  - Child
MH  - Child, Preschool
MH  - *Cord Blood Stem Cell Transplantation/adverse effects/standards/statistics & 
      numerical data
MH  - Disease-Free Survival
MH  - Female
MH  - Graft Survival
MH  - Graft vs Host Disease/epidemiology/etiology/prevention & control
MH  - Graft vs Leukemia Effect/immunology
MH  - Granulocyte Colony-Stimulating Factor/pharmacology
MH  - HLA Antigens/immunology
MH  - Hematologic Neoplasms/mortality/*therapy
MH  - *Histocompatibility
MH  - Humans
MH  - Incidence
MH  - Infant, Newborn
MH  - Life Tables
MH  - Male
MH  - Neural Tube Defects/mortality/therapy
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Registries/statistics & numerical data
MH  - *Tissue Donors
MH  - Transplantation Conditioning/mortality/statistics & numerical data
MH  - Treatment Outcome
EDAT- 2004/03/31 05:00
MHDA- 2004/05/18 05:00
CRDT- 2004/03/31 05:00
PHST- 2003/11/17 00:00 [received]
PHST- 2004/01/06 00:00 [revised]
PHST- 2004/01/16 00:00 [accepted]
PHST- 2004/03/31 05:00 [pubmed]
PHST- 2004/05/18 05:00 [medline]
PHST- 2004/03/31 05:00 [entrez]
AID - S0301472X04000256 [pii]
AID - 10.1016/j.exphem.2004.01.002 [doi]
PST - ppublish
SO  - Exp Hematol. 2004 Apr;32(4):397-407. doi: 10.1016/j.exphem.2004.01.002.