PMID- 15051832
OWN - NLM
STAT- MEDLINE
DCOM- 20040506
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 134
IP  - 4
DP  - 2004 Apr
TI  - Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or 
      deficient in folate promotes early atherosclerotic inflammatory processes.
PG  - 825-30
AB  - High homocysteine levels in vitro promote the expression of inflammatory agents 
      responsible for atherogenesis. We investigated the long-term effects of elevated 
      plasma homocysteine on the expression of inflammatory molecules and attempted to 
      elucidate their mechanisms. Male Sprague-Dawley rats (n = 36) were randomly 
      divided into 3 groups, which received the control AIN-93G diet, the control diet 
      plus 10 g/kg of L-methionine, or that diet without folate (0 m/kg) for 14 wk. 
      Mild hyperhomocysteinemia was then induced in both experimental groups. The 
      mildly hyperhomocysteinemic rats had markedly increased expression of 
      intracellular adhesion molecule-1 (ICAM-1) in the aorta and elevated serum levels 
      of monocyte chemoattractant protein-1 (MCP-1), compared to the control rats. The 
      activation of nuclear factor kappaB and formation of nitrotyrosine in the aorta 
      were greater in rats with mild hyperhomocysteinemia than in control rats. Serum 
      levels of malonyldialdehyde (MDA) were higher in mildly hyperhomocysteinemic rats 
      than in control rats. These results suggest that the oxidative stress resulting 
      from elevated plasma homocysteine stimulates the activation of nuclear factor 
      kappaB, and consequently increases the expression of the inflammatory factors in 
      vivo. Such an effect may contribute to atherogenesis by enhancing the 
      inflammatory response of the vascular endothelium.
FAU - Zhang, Ruifen
AU  - Zhang R
AD  - Department of Clinical Nutrition, Sun Yat-sen University, Guangzhou 510080, 
      China.
FAU - Ma, Jing
AU  - Ma J
FAU - Xia, Min
AU  - Xia M
FAU - Zhu, Huilian
AU  - Zhu H
FAU - Ling, WengHua
AU  - Ling W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Chemokine CCL2)
RN  - 0 (NF-kappa B)
RN  - 0 (Nitrites)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 3604-79-3 (3-nitrotyrosine)
RN  - 42HK56048U (Tyrosine)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 935E97BOY8 (Folic Acid)
RN  - AE28F7PNPL (Methionine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Aorta/chemistry/metabolism
MH  - Arteriosclerosis/*etiology/metabolism
MH  - Chemokine CCL2/blood
MH  - *Diet
MH  - Endothelium, Vascular/metabolism
MH  - Folic Acid/*administration & dosage
MH  - Folic Acid Deficiency/complications
MH  - Hyperhomocysteinemia/*complications/etiology
MH  - Inflammation/*etiology
MH  - Intercellular Adhesion Molecule-1/analysis
MH  - Male
MH  - Malondialdehyde/blood
MH  - Methionine/*administration & dosage
MH  - NF-kappa B/metabolism
MH  - Nitric Oxide Synthase/metabolism
MH  - Nitrites/blood
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tyrosine/*analogs & derivatives/metabolism
EDAT- 2004/03/31 05:00
MHDA- 2004/05/07 05:00
CRDT- 2004/03/31 05:00
PHST- 2004/03/31 05:00 [pubmed]
PHST- 2004/05/07 05:00 [medline]
PHST- 2004/03/31 05:00 [entrez]
AID - S0022-3166(23)02719-0 [pii]
AID - 10.1093/jn/134.4.825 [doi]
PST - ppublish
SO  - J Nutr. 2004 Apr;134(4):825-30. doi: 10.1093/jn/134.4.825.