PMID- 15054397
OWN - NLM
STAT- MEDLINE
DCOM- 20041207
LR  - 20091119
IS  - 1018-4813 (Print)
IS  - 1018-4813 (Linking)
VI  - 12
IP  - 6
DP  - 2004 Jun
TI  - Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic 
      disorder and control individuals representing European and American populations.
PG  - 505-8
AB  - Investigation of the co-occurrence of panic and phobic disorders with joint 
      laxity led to the identification of interstitial duplications involving human 
      chromosome 15q24-26 (named 'DUP25') in a Spanish population. DUP25 was observed 
      in 97% of patients and in 7% of control individuals. In the present study, we 
      used two different methods to detect DUP25: high-throughput molecular gene dosage 
      analysis and fluorescence in situ hybridization (FISH). We evaluated 56 
      lymphoblastoid cell lines derived from 26 unrelated patients with panic disorder 
      obtained from several European and American populations and 30 normal controls. 
      We could not find any cell line showing a result consistent with DUP25. These 
      data do not support any association of DUP25 with panic disorder.
FAU - Zhu, Guanshan
AU  - Zhu G
AD  - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Bartsch, Oliver
AU  - Bartsch O
FAU - Skrypnyk, Cristina
AU  - Skrypnyk C
FAU - Rotondo, Alessandro
AU  - Rotondo A
FAU - Akhtar, Longina A
AU  - Akhtar LA
FAU - Harris, Claudia
AU  - Harris C
FAU - Virkkunen, Matti
AU  - Virkkunen M
FAU - Cassano, Giovanni
AU  - Cassano G
FAU - Goldman, David
AU  - Goldman D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Americas
MH  - Case-Control Studies
MH  - *Chromosomes, Human, Pair 15
MH  - Europe
MH  - Female
MH  - Gene Dosage
MH  - *Gene Duplication
MH  - Genetics, Population
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/*physiology
MH  - Male
MH  - Middle Aged
MH  - Panic Disorder/*genetics
MH  - Receptor, trkC/*genetics
MH  - Spain
EDAT- 2004/04/01 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/04/01 05:00
PHST- 2004/04/01 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/04/01 05:00 [entrez]
AID - 5201181 [pii]
AID - 10.1038/sj.ejhg.5201181 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2004 Jun;12(6):505-8. doi: 10.1038/sj.ejhg.5201181.