PMID- 15056832
OWN - NLM
STAT- MEDLINE
DCOM- 20041021
LR  - 20220317
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 68
IP  - 4
DP  - 2004 Apr
TI  - Very low frequency power of heart rate variability is a powerful predictor of 
      clinical prognosis in patients with congestive heart failure.
PG  - 343-7
AB  - BACKGROUND: The present study examined whether the very low frequency (VLF) power 
      of heart rate variability (HRV) is predictive of clinical prognosis in patients 
      with congestive heart failure (CHF). METHOD AND RESULTS: The study recruited 54 
      consecutive CHF patients with emergency admission because of exacerbation of 
      pulmonary congestion. Holter monitoring was performed after improvement of 
      pulmonary congestion. The frequency components of HRV were calculated in the 
      frequency domain (VLF, low frequency (LF), high frequency (HF), total power (TP) 
      and the ratio of LF to HF power). The left ventricular ejection fraction was 
      calculated, and plasma brain natriuretic peptide (BNP) and norepinephrine were 
      also measured at discharge. Within a mean follow-up period of 19.8 +/- 11.7 
      months, 18 patients experienced cardiovascular events; 7 patients died and 11 
      patients required rehospitalization because of worsening of CHF. In univariate 
      analysis, diabetes mellitus (DM), BNP and New York Heart Association (NYHA) 
      functional class were significant as risk factors for cardiac events. VLF power, 
      LF power and TP were the strong predictors for cardiac events in HRV. In 
      multivariate analysis, VLF power predicted cardiac events independently of LF 
      power, TP, DM, BNP and NYHA functional class (chi-square=6.24, p=0.01). 
      CONCLUSIONS: VLF power is an independent risk predictor in patients with CHF.
FAU - Hadase, Mitsuyoshi
AU  - Hadase M
AD  - Department of Cardiology, Kyoto Prefectural University of Medicine, Japan. 
      hadase@msj.biglobe.ne.jp
FAU - Azuma, Akihiro
AU  - Azuma A
FAU - Zen, Kan
AU  - Zen K
FAU - Asada, Satoshi
AU  - Asada S
FAU - Kawasaki, Tatsuya
AU  - Kawasaki T
FAU - Kamitani, Tadaaki
AU  - Kamitani T
FAU - Kawasaki, Shingo
AU  - Kawasaki S
FAU - Sugihara, Hiroki
AU  - Sugihara H
FAU - Matsubara, Hiroaki
AU  - Matsubara H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cheyne-Stokes Respiration/epidemiology
MH  - Cohort Studies
MH  - Comorbidity
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/mortality/*physiopathology
MH  - *Heart Rate
MH  - Humans
MH  - Life Tables
MH  - Male
MH  - Middle Aged
MH  - Norepinephrine/blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Survival Analysis
EDAT- 2004/04/02 05:00
MHDA- 2004/10/22 09:00
CRDT- 2004/04/02 05:00
PHST- 2004/04/02 05:00 [pubmed]
PHST- 2004/10/22 09:00 [medline]
PHST- 2004/04/02 05:00 [entrez]
AID - 10.1253/circj.68.343 [doi]
PST - ppublish
SO  - Circ J. 2004 Apr;68(4):343-7. doi: 10.1253/circj.68.343.