PMID- 15056877
OWN - NLM
STAT- MEDLINE
DCOM- 20041207
LR  - 20151119
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 68
IP  - 3
DP  - 2004 Mar
TI  - The effects of maternal mild protein restriction on stroke incidence and blood 
      pressure in stroke-prone spontaneously hypertensive rats (SHRSP).
PG  - 488-94
AB  - The effect of maternal protein restriction during pregnancy on the offspring's 
      blood pressure was assessed in stroke-prone spontaneously hypertensive rats 
      (SHRSP) which are genetically predisposed to hypertension and stroke. After the 
      confirmation of pregnancy, the control group was given a 20% casein diet, and the 
      low-protein group was fed a 9% casein diet. After the confirmation of delivery, 
      commercial feed was given to both of the groups. No differences were seen between 
      the control and low-protein offspring in regard to body weight, blood pressure 
      elevation, or life span. One percent saline solution was put in the control and 
      low-protein groups after the age of 11 weeks. Blood pressure increased markedly 
      in the low-protein group, on the blood pressure level in the low-protein group on 
      week 2 after salt loading (242+/-6 mmHg) was significantly higher than that in 
      the control group (223+/-9 mmHg; p<0.05). The survival duration was significantly 
      shorter in the low-protein group (113+/-4 days) than in the control group 
      (135+/-22 days; p<0.05). These results suggest that maternal protein malnutrition 
      in SHRSP exerted a high salt sensitivity and a malignant influence on stroke 
      incidence on offspring.
FAU - Otani, Lila
AU  - Otani L
AD  - Division of Advanced Life Sciences, Graduate School of Agriculture, Kinki 
      University, Nakamachi, Nara, Japan.
FAU - Shirasaka, Norifumi
AU  - Shirasaka N
FAU - Yoshizumi, Hajime
AU  - Yoshizumi H
FAU - Murakami, Tetsuo
AU  - Murakami T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Blood Pressure/*physiology
MH  - Diet, Protein-Restricted
MH  - Female
MH  - Fetus/metabolism
MH  - Hypertension/*etiology/physiopathology
MH  - Incidence
MH  - Longevity
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Risk Factors
MH  - Sodium Chloride/pharmacology
MH  - Stroke/epidemiology/*etiology
MH  - Weight Gain
EDAT- 2004/04/02 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/04/02 05:00
PHST- 2004/04/02 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/04/02 05:00 [entrez]
AID - 10.1271/bbb.68.488 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2004 Mar;68(3):488-94. doi: 10.1271/bbb.68.488.